Results 301 to 310 of about 134,599 (345)

Identifying Therapeutic Targets for Bronchial Asthma: Systematic Druggable Genome‐Wide Mendelian Randomization

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background The treatment and prevention of bronchial asthma continue to present significant challenges. Mendelian randomization (MR) has been extensively employed to identify novel therapeutic targets. Consequently, we conducted a systematic MR analysis across the druggable genome to identify potential therapeutic targets for asthma.
Haijiao Wang, Peng Zhang, Hongpeng Yu, Li Shi, Tan Wang   +4 more
wiley   +1 more source

Epsin1 enforces a condensation-dependent checkpoint for ubiquitylated cargo during clathrin-mediated endocytosis. [PDF]

Nat Commun
Sarkar S, Liu HY, Yuan F, Malady BT, Wang L, Lafer EM, Perez J, Huibregtse JM, Stachowiak JC.   +8 more
europepmc   +1 more source

Exosome‐Enhanced Injectable Hydrogels: A Comprehensive Review on Their Emerging Role in Wound Healing

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims The escalation of chronic wounds necessitates advanced therapeutic strategies beyond current interventions. Hydrogel dressings, particularly injectable hydrogels, offer promising solutions due to their water absorption capacity, structural resilience, and ease of application.
Mohammad Ebrahim Astaneh, Lalji Baldaniya, Abhayveer Singh, Ahmad Hussen, Alireza Hashemzadeh, Narges Fereydouni   +5 more
wiley   +1 more source

Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes

Journal of Cellular Physiology, Volume 241, Issue 1, January 2026.
Abstract Preservation of the insulin‐sensitive glomerular podocyte is imperative for normal kidney function. The protein tyrosine phosphatases (PTPs), protein tyrosine phosphatase 1B (PTP1B), T‐cell protein tyrosine phosphatase (TCPTP), and Src homology phosphatase 2 (SHP2) are established regulators of insulin signaling in vivo and implicated in renal
Grace LeBleu, Ming‐Fo Hsu, Yoshihiro Ito, Suh‐Yuen Liang, Kwan‐Liu Ma, Tzu‐Ching Meng, Fawaz G. Haj   +6 more
wiley   +1 more source

In situ cryo-electron tomography of vaccinia virus exit from infected cells

Hernandez-Gonzalez M, Nans A, Calcraft T, Rosenthal P, Way M.   +4 more
europepmc   +1 more source

Tetraspanin SfCD9 as a Key Membrane Binding Factor of SRBSDV P10 Facilitates Viral Entry Into Sogatella furcifera Midgut Epithelial Cells via Clathrin-Mediated Endocytosis. [PDF]

Mol Plant Pathol
Gao S, Li L, Zeng M, Xie L, Li J, Zhou X, Wu J.   +6 more
europepmc   +1 more source

Cholesterol Deficiency Directs Autophagy‐Dependent Secretion of Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
Inhibition of cholesterol biosynthesis within models of rare disease and cancer causes increased release of small extracellular vesicles (sEVs) with distinct biological properties. Mechanistically, cholesterol depletion leads to impaired autophagic flux, redirection of autophagosomes to late endosomes, and subsequently increased sEV secretion ...
Jazmine D. W. Yaeger, Sonali Sengupta, Austin L. Walz, Mayu Morita, Terry K. Morgan, Paola D. Vermeer, Kevin R. Francis   +6 more
wiley   +1 more source

Exploring the Spatial Limits of Extracellular Vesicles-Mediated Intercellular Communication. [PDF]

J Extracell Vesicles
Colombo F, Nimkar K, Norton EG, Lovat F, Cocucci E.   +4 more
europepmc   +1 more source

Top‐Down Proteomics Study of Aging and Sexual Dimorphism of Zebrafish Brains

Journal of Mass Spectrometry, Volume 61, Issue 1, January 2026.
ABSTRACT Aging significantly impacts brain function and increases susceptibility to neurodegenerative diseases, with notable sex dimorphism observed in aging‐related dementia, such as Alzheimer's disease. To better understand the molecular mechanisms of aging and dementia, it is essential to globally and accurately characterize biomolecules (e.g ...
Mehrdad Falamarzi Askarani, William Poulos, Maryam Rahimzadeh Dashtaki, Seyed Amirhossein Sadeghi, Jose B. Cibelli, Fei Fang, Liangliang Sun   +6 more
wiley   +1 more source