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Biotechnology Advances, 2008
Natural antibiotics are almost universal secondary metabolites, not essential for the growth of the producing organisms generally produced at low growth rates or after growth has ceased. Clavulanic acid (CA), a naturally occurring powerful inhibitor of bacterial beta-lactamases is a major beta-lactam antibiotic produced by organism Streptomyces ...
Shrikant A Survase, Rekha S Singhal
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Natural antibiotics are almost universal secondary metabolites, not essential for the growth of the producing organisms generally produced at low growth rates or after growth has ceased. Clavulanic acid (CA), a naturally occurring powerful inhibitor of bacterial beta-lactamases is a major beta-lactam antibiotic produced by organism Streptomyces ...
Shrikant A Survase, Rekha S Singhal
exaly +3 more sources
On the absorption of clavulanic acid
Biopharmaceutics & Drug Disposition, 1988AbstractIt was not possible to computer fit oral clavulanic acid data using exponential or model equations incorporating a single exponential defining the absorption phase. Using the Loo‐Riegelman method three phases of the absorption process became apparent, an initial slow phase, a more rapid phase and a final slow phase, contributing approximately ...
G D, Allen, P E, Coates, B E, Davies
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Polarographic determination of clavulanic acid
Journal of Pharmaceutical and Biomedical Analysis, 1991A method is proposed for the determination of clavulanic acid by differential pulse polarography. The electroactive product was obtained by hydrolysis in sulphuric medium. It shows a reduction peak, that can be used analytically, at -0.75 V (vs SCE).
C, González Pérez +2 more
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The disposition of clavulanic acid in man
Xenobiotica, 1986Following oral administration of potassium 14C-clavulanate to four human subjects, at least 73% of the radioactive dose was absorbed. The mean absolute bioavailability was 64%. Absorption was rapid with peak plasma concentrations of radioactivity and clavulanic acid (2-6 micrograms/ml) occurring between 45 min and three hours after dosing.
G C, Bolton +4 more
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Biochemistry and Action of Clavulanic Acid
Scottish Medical Journal, 1982The destruction of amoxycillin by β-lactamase action represents an important mechanism of bacterial resistance to the drug. Data is presented to illustrate that clavulanic acid used in the form of its potassium salt inhibits the amoxycillin destroying action of many different types of β-lactamase for example: the staphylococcal enzyme, the clinically ...
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Amoxicillin/amoxicillin/clavulanic-acid/clavulanic-acid
Reactions Weekly, 2023openaire +1 more source