Results 31 to 40 of about 360,316 (244)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The influence of cyclic loading-unloading rates on the uniaxial mechanical anisotropy of coal

Scientific Reports
In this study, the influence of the loading-unloading rate on the uniaxial mechanical anisotropy of coal was investigated via uniaxial compressive tests, acoustic emission (AE) monitoring, digital image correlation (DIC), and a series of coal specimens ...
Duo Xu, Honghua Song, Like Zhao, Guoqing Tang, Shide Hu, Chenxi Duan, Yunting Song   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Surface deformation characteristics of shallow buried and rapidly advancing longwall face in Jinjie coal mine

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
In high-intensity mining operations in western China, shallow burial depths and rapid advancement rates induce rapid surface responses, significant deformation, and pronounced crack development.
Xinjie Liu, Anmin He, Xiaobin Li, Xiaolong Wang, Yongqiang Zhao   +4 more
doaj   +1 more source

Stage-Wise Simulation for Operational Stability Evaluation of Seasonal Heat Storage in Abandoned Coal Mines

Energies
The development of coal resources has created a large number of underground mined-out spaces, which can be utilized for cross-seasonal thermal storage through underground reservoirs to achieve seasonal heat storage.
Wenying Tang, Jiawei Tang, Qiang Guo, Haiqin Zhang, Changhao Feng, Xiaolin He, Zixu Hu, Xi Wu   +7 more
doaj   +1 more source

Peningkatan Kualitas Tahu Mbak Trisni Di Kecamatan Percut Sei Tuan

Dinamisia, 2020
The business of Tofu Mbak TRISNI located in Percut Sei Tuan has produced about 2 years. The Problems in the partner's efforts are: 1) The partner has not yet had the knowledge and understanding of the quality of clean water and is worthy tobe used for ...
Herbert Sipahutar, Makmur Sirait, Mukti Hamjah Harahap, Irfandi, Deo Demonta Panggabean, Anggriyani, Dedy Husrizal Syah   +6 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Performance Evaluation of Heat Storage in a Full Operation Cycle of Cross-Seasonal Thermal Energy Storage Systems in Coal Mine Underground Reservoirs

Applied Sciences
Coal mining has generated a large amount of underground space, which has traditionally been reused mostly as mine wastewater storage. Given the excellent thermal insulation properties of these mine reservoirs, their potential for seasonal energy storage ...
Wenying Tang, Jiawei Tang, Qiang Guo, Haiqin Zhang, Changhao Feng, Yilong Yuan, Xiaolin He, Zixu Hu   +7 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source