Results 31 to 40 of about 375,248 (265)

Surface deformation characteristics of shallow buried and rapidly advancing longwall face in Jinjie coal mine

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
In high-intensity mining operations in western China, shallow burial depths and rapid advancement rates induce rapid surface responses, significant deformation, and pronounced crack development.
Xinjie Liu, Anmin He, Xiaobin Li, Xiaolong Wang, Yongqiang Zhao   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Performance Evaluation of Heat Storage in a Full Operation Cycle of Cross-Seasonal Thermal Energy Storage Systems in Coal Mine Underground Reservoirs

Applied Sciences
Coal mining has generated a large amount of underground space, which has traditionally been reused mostly as mine wastewater storage. Given the excellent thermal insulation properties of these mine reservoirs, their potential for seasonal energy storage ...
Wenying Tang, Jiawei Tang, Qiang Guo, Haiqin Zhang, Changhao Feng, Yilong Yuan, Xiaolin He, Zixu Hu   +7 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Stage-Wise Simulation for Operational Stability Evaluation of Seasonal Heat Storage in Abandoned Coal Mines

Energies
The development of coal resources has created a large number of underground mined-out spaces, which can be utilized for cross-seasonal thermal storage through underground reservoirs to achieve seasonal heat storage.
Wenying Tang, Jiawei Tang, Qiang Guo, Haiqin Zhang, Changhao Feng, Xiaolin He, Zixu Hu, Xi Wu   +7 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

CLEAN WATER AND HOW TO GET IT. [PDF]

Journal of the American Chemical Society, 1907
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openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Surface damage reduction effect of ultra-high working face in Shangwan coal mine

Scientific Reports
Green mining is the basic background of high-quality mining, and source reduction is the most important part, among which the optimization of working face height and length is the most active.
L. I. U. Xinjie, Yang Yingming, Zhao Yongqiang, WANG Xiaolong, Liu Gang, Xu Zhuhe   +5 more
doaj   +1 more source