Results 31 to 40 of about 321,393 (268)

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Crystal structure of μ-oxido-bis{2,2-[ethylidene(bis-(nitrilomethylidyne))] diphenolato} iron(III), [Fe2O(C16H14N2)2]·2.5(C7H8), C49.50H48Fe2N4O5

Zeitschrift für Kristallographie - New Crystal Structures, 2012
C49.50H48Fe2N4O5, monoclinic, P21/c (no. 14), a = 12.7141(9) Å, b = 16.559(1) Å, c = 21.164(2) Å, β = 100.628(1)°, V = 4379.4 Å3, Z = 4, Rgt(F) = 0.0624, wRref(F2) = 0.1592, T = 187 K.
Li Liang-Zhao, Song Guo-Lin, Tang Guo-Yi
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Calibration and performance evaluation of PM_2.5 and NO₂ air quality sensors for environmental epidemiology [PDF]

Atmospheric Measurement Techniques
Over the past few decades, the study and the use of air quality sensors have significantly increased, leading to a wealth of experience and a deeper understanding of their strengths and limitations.
M. Chacón-Mateos, M. Chacón-Mateos, H. García-Salamero, B. Laquai, U. Vogt   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Optimal design of liquid cooling structures for superfast charging cable cores under a high current load

Case Studies in Thermal Engineering
Superchargers have become a focus of much research into new-energy vehicles, for which the cooling of high-current cable cores is a key problem that needs to be solved.
Yue Wu, He Yu, Jinhao Zhang, Xixia Xu, Ruoyu Dai, Wenzhi Liu, He Lv, Yiming Xu, Qinfeng Wang, Hongzhou He, Jieqing Zheng   +10 more
doaj   +1 more source

Radiology imaging equipment and accessories as possible fomites of nosocomial pathogens

Journal of Infection in Developing Countries, 2022
Introduction: Radiology is a technical service that provides medical imaging for all sectors of healthcare. Hospital-acquired infections (HAIs) is a major challenge in radiology and this is exacerbated in contexts where the healthcare system is unable ...
Isaac Agyekum Adomako, Dalene Venter, Eric Sampane Donkor, Penelope Engel-Hills   +3 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

In Situ Synthesis of CoMoO₄ Microsphere@rGO as a Matrix for High-Performance Li-S Batteries at Room and Low Temperatures

Molecules
Lithium–sulfur batteries (Li-S batteries) have attracted wide attention due to their high theoretical energy density and the low cost of sulfur cathode material.
Ronggang Zhang, Haiji Xiong, Jia Liang, Jinwei Yan, Dingrong Deng, Yi Li, Qihui Wu   +6 more
doaj   +1 more source