Results 51 to 60 of about 2,227,952 (336)

Influences of an Arrow’s Aerodynamic Pressure Center on Recurve Bow Shooting

open access: yesApplied Sciences
An arrow’s attack angle continuously changes during its flight, which affects the position of the aerodynamic pressure center. To account for the offset between the aerodynamic pressure center and the center of mass of an arrow in recurve bow shooting ...
Wenfeng Shen   +5 more
doaj   +1 more source

Robust surface electronic properties of topological insulators: Bi2Te3 films grown by molecular beam epitaxy [PDF]

open access: yes, 2011
The surface electronic properties of the important topological insulator Bi2Te3 are shown to be robust under an extended surface preparation procedure which includes exposure to atmosphere and subsequent cleaning and recrystallization by an optimized in ...
Gruetzmacher, D.   +6 more
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Crystal structure of μ-oxido-bis{2,2-[ethylidene(bis-(nitrilomethylidyne))] diphenolato} iron(III), [Fe2O(C16H14N2)2]·2.5(C7H8), C49.50H48Fe2N4O5

open access: yesZeitschrift für Kristallographie - New Crystal Structures, 2012
C49.50H48Fe2N4O5, monoclinic, P21/c (no. 14), a = 12.7141(9) Å, b = 16.559(1) Å, c = 21.164(2) Å, β = 100.628(1)°, V = 4379.4 Å3, Z = 4, Rgt(F) = 0.0624, wRref(F2) = 0.1592, T = 187 K.
Li Liang-Zhao, Song Guo-Lin, Tang Guo-Yi
doaj   +1 more source

Modeling of Complex Parts for Industrial WaterJet Cleaning [PDF]

open access: yes, 2019
Industrial high-pressure waterjet cleaning is common to many industries. The modeling in this paper functions inside a collaborative robotic framework for high mix, low volume processes where human robot collaboration is beneficial.
James, Braden
core   +2 more sources

SPMHD simulations of Structure Formation [PDF]

open access: yes, 2018
The intracluster medium of galaxy clusters is permeated by {\mu}G magnetic fields. Observations with current and future facilities have the potential to illuminate the role of these magnetic fields play in the astrophysical processes of galaxy clusters ...
Barnes, David J.   +3 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Optimal design of liquid cooling structures for superfast charging cable cores under a high current load

open access: yesCase Studies in Thermal Engineering
Superchargers have become a focus of much research into new-energy vehicles, for which the cooling of high-current cable cores is a key problem that needs to be solved.
Yue Wu   +10 more
doaj   +1 more source

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