Results 41 to 50 of about 3,444 (214)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Feasibility Study on the Use of NO₂ and PM_2.5 Sensors for Exposure Assessment and Indoor Source Apportionment at Fixed Locations

Sensors
Recent advances in sensor technology for air pollution monitoring open new possibilities in the field of environmental epidemiology. The low spatial resolution of fixed outdoor measurement stations and modelling uncertainties currently limit the ...
Miriam Chacón-Mateos, Erika Remy, Uta Liebers, Frank Heimann, Christian Witt, Ulrich Vogt   +5 more
doaj   +1 more source

The compatibility between some the materials used in cleaning to improve their effectiveness in cleaning oil paintings

Journal of Architecture, Art & Humanistic Science, 2020
This study examined the compatibility of some cleaning materials to reach compounds that are more effective and help to raise the efficiency rates of cleaning stains from the surface of oil paintings.
Ahmed Mamdouh Zaki
doaj   +1 more source

Normal Workflow and Key Strategies for Data Cleaning Toward Real-World Data: Viewpoint

Interactive Journal of Medical Research, 2023
With the rapid development of science, technology, and engineering, large amounts of data have been generated in many fields in the past 20 years.
Manping Guo, Yiming Wang, Qiaoning Yang, Rui Li, Yang Zhao, Chenfei Li, Mingbo Zhu, Yao Cui, Xin Jiang, Song Sheng, Qingna Li, Rui Gao   +11 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Consequences of the Clean Water Act and the Demand for Water Quality [PDF]

SSRN Electronic Journal, 2017
Since the 1972 U.S. Clean Water Act, government and industry have invested over $1 trillion to abate water pollution, or $100 per person-year. Over half of U.S. stream and river miles, however, still violate pollution standards. We use the most comprehensive set of files ever compiled on water pollution and its determinants, including 50 million ...
Keiser, David, Shapiro, Joseph
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Innovative Application of a Synergistic ATP Bioluminescence Assay–Video-in-Video Visualization–Traceability System for Closed-Loop Management of the Central Sterile Supply Department

Sterile Supply
ObjectiveTo investigate the effectiveness of the three-technology synergistic system integrating adenosine triphosphate (ATP) bioluminescence assay, video-in-video visualization inspection, and intelligent traceability in the closed-loop management of ...
Xiang Chen, Min Zhu
doaj   +1 more source