Results 131 to 140 of about 22,575 (297)

Evaluation of Awareness and Perception of Clear Aligner Orthodontic Treatment Among Students of Hawler Medical University.

Erbil Dental Journal
Background and Objectives: The growing emphasis on appearance has led to an increased   interest in orthodontic treatment among adults, particularly those who are highly self-conscious about their looks.
Maryam Fouad Bilal, Ahmed Qesim Ali, Layard Khalil Ibrahim   +2 more
doaj  

Dentists’ Perception of Mysmartalign Clear Aligner Treatment

Journal of Pharmacy and Bioallied Sciences
Aim and ObjectiveTo assess the dentist perception of efficiency, treatment outcome, and stability of the tooth movement treated with mysmartalign clear aligner therapy (MSA CAT).
Shaga I. Bevin, Priya K, Ramar Selvakumar, Srinidhi S, Mohan G. Chandra, Ranganathan Sukanya, Moulvi S. M. M   +6 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

The Effect of Initial Orthodontic Therapy with Clear Aligners and Fixed Appliances on Microbial Profiles and Clinical Parameters

Journal of the California Dental Association
Background Orthodontic appliances hinder proper oral hygiene, leading to plaque retention and biofilm formation which can cause dental diseases. This study investigates the initial impact of orthodontic treatment with fixed appliances versus clear ...
Megan Haug, Andrew Hopkins, Emily Duong, Kim-Sa Kelly, Julia Esfandi, Bhumika Shokeen, Tingxi Wu, Renate Lux   +7 more
doaj   +1 more source

Tooth Whitening in Association with Clear Aligner Treatment

, 2019
The ever-increasing patient demand for “invisible” orthodontic appliances has led to major growth in the clear aligner industry.1 Not only do align- ers have a minimal esthetic impact, but they are also an efficacious means of moving teeth into the ...
Lombardo L., Cremonini F., Siciliani G., Oliverio T.   +3 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Auxiliaries of Clear Aligner Therapy

Osol Journal for Medical Sciences
Background: clear Aligner Therapy (CAT) has transformed orthodontic treatment by offering a comfortable, discreet, and removable alternative to traditional braces. Initially designed for minor tooth movements, but has expanded its reach thanks to the integration of various auxiliaries and advancements in biomechanics.
Amna Khalid Hamid, Tabark Ahmed Jumaa, Raghda Dhiaa, Deema Saad   +3 more
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source