Results 71 to 80 of about 22,575 (297)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

A Finite Element Analysis Of Maxilla Protraction Using Clear Aligners

open access: yesInternational Dental Journal
Aim or purpose: To investigate the displacement and stress distribution of the maxilla and its sutures using clear aligners compared with fixed appliance during maxillary protraction by finite element analysis.
Chenlu Liu   +3 more
doaj   +1 more source

Aligners: The Science of Clear Orthodontics

open access: yesInternational Journal of Dental and Medical Specialty, 2020
Since their inception, clear aligners have undergone multitude of advancements that aimed to make the orthodontic treatment less conspicuous. Used for moving teeth for alignment and creating healthy and beautiful smiles, like many other orthodontic appliances, clear aligners have proven to be a much more comfortable and esthetic alternative.
openaire   +1 more source

Comparative Analysis of Two Clear Aligner Systems for Orthodontic Refinement

open access: yes, 2023
Introduction: The 3M ClarityTM Clear Aligner System differs from Invisalign in a variety of ways, such as algorithm, precision attachments, precision cuts, and appliance design.
Arnao, Ashley
core  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Management of the anterior open bite using clear aligner therapy and surgery-first: Case example and scoping review of the literature

open access: yesDentistry Review
Background: The anterior open bite is challenging skeletal facial discrepancy and often requires a combined orthodontic and surgical approach to treatment.
Marshall F. Newman, Joshua Stewart
doaj   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Distribution of orthodontic force during canine retraction in clear aligner treatment [PDF]

open access: yes
Orthodontic clear aligners have rapidly gained popularity. In cases of tooth extraction during clear aligner treatment, a bowing effect occurs, where the tooth tilts toward the extraction socket, in contrast to the simulation.
SATO, Aya   +7 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

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