Results 91 to 100 of about 1,777,378 (290)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effect of Clear Aligner Therapy on Jaw Motor Function [PDF]

, 2019
Recent evidence indicates that clear aligner therapy (CAT) induces mild to moderate tooth and jaw muscle pain. This study aimed to measure the effect of CAT on the electromyographic (EMG) activity of the masseter.
Lou, Tiantong
core   +2 more sources

Factors Affecting Attachment Loss in Clear Aligner Treatment: A Prospective Clinical Study

Bezmiâlem Science
Objective: This study aimed to evaluate the incidence of composite attachment loss in patients undergoing clear aligner treatment and to identify patient-, tooth-, and treatment-related factors associated with attachment debonding.
Şerife ŞAHİN, Hümeyra ÜNSAL, Gökmen KURT   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

How Efficient Are Clear Aligners? Clear Aligners vs Traditional Orthodontic Treatment: A Systematic Review [PDF]

, 2014
Purpose:The purpose of the present review is to update knowledge of the literature and better understand the efficiency and abilities of clear aligners and to clarify their indications for use.Materials and Method:The study question was defined as ‘‘How ...
Ayşegül Kovan, Mustafa Ates, Sibel Biren, Yasemin Bahar Acar   +3 more
core   +1 more source

Finding Aid for the Clear Lake Area Neighborhood Newsletter Collection (#2016-0017) [PDF]

, 2018
The Clear Lake Area Neighborhood Newsletter Collection contains original local community newspapers and newsletters for towns and cities in the greater Clear Lake area of Houston, Texas.

core   +1 more source

Movement of anterior teeth using clear aligners: a three-dimensional, retrospective evaluation

Progress in Orthodontics, 2018
Background Clear aligner treatment offers several advantages, but the available literature shows that some kind of tooth movements are unpredictable.
Michele Tepedino, Valeria Paoloni, Paola Cozza, Claudio Chimenti   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Comparative evaluation of apical root resorption in adult patients treated with clear aligners and fixed orthodontic appliances using CBCT

Acta Odontologica Scandinavica
Background: Orthodontically induced external apical root resorption is a common iatrogenic effect of tooth movement. With the increasing use of clear aligner therapy, it is important to evaluate whether its biomechanics reduce root resorption compared ...
Rakhi Issrani, Abdullah Hammad Alshammari, Mohammad Raji Alrwuili, Mohammed Ahmed Aljabab, Nasser Attallah Alenzi, Poonam Joshi, Yousef T. Aldoseri   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source