Results 191 to 200 of about 86,255 (232)

Beyond celiac disease: the potential role of gluten in Hashimoto's thyroiditis. [PDF]

Front Endocrinol (Lausanne)
Fan X, Li X, Fan Y, Fan Y.
europepmc   +1 more source

External Control Arms in Japan: A Systematic Case Analysis of Documented Regulatory Implementation and Uncertainty Management

Clinical Pharmacology &Therapeutics, EarlyView.
External control arms (ECAs) have emerged as important tools to provide benchmark evidence on comparator effectiveness and thereby support regulatory decision making in situations where randomized controlled trials are difficult to conduct. However, how key methodological elements for ECAs are documented and implemented in practice and how residual ...
Suguru Okami, Alexandros Sagkriotis
wiley   +1 more source

Assessment of patient preferences in digital health trials: procedure development and implementation in a preference-based trial. [PDF]

BMJ Open
Barth J, Thomae AV, Tietjen AK, Witt CM.
europepmc   +1 more source

Clinical Function Assignment of NAT2 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel

Clinical Pharmacology &Therapeutics, EarlyView.
NAT2 encodes arylamine N‐acetyltransferase 2, a key enzyme in the phase II metabolism of arylamines and arylhydrazines. NAT2 is highly polymorphic, resulting in variable distributions of rapid and poor metabolizers across global populations. Here, we detail the process undertaken by the Clinical Pharmacogenetics Implementation Consortium (CPIC) NAT2 ...
Bailey M. Tibben, David W. Hein, Michelle Whirl‐Carrillo, Andrea Gaedigk, Michael T. Eadon, Rodney F. Minchin, Sotiria Boukouvala, Adalberto Rezende Santos, Roseann S. Donnelly, José A. G. Agúndez, Kelly E. Caudle   +10 more
wiley   +1 more source

"It's really about something! I can save the patient a lot of suffering if I get him to do it": between care and coercion in the use of non-invasive ventilation. [PDF]

BMC Health Serv Res
Seidlein AH, Jöbges S.
europepmc   +1 more source

Mitochondrial replacement techniques for treating infertility. [PDF]

J Med Ethics
Braun E.
europepmc   +1 more source

<i>In silico</i> prediction and IgE serum screening for potential allergenicity of novel foods-a case of fungal biomass Fermotein®. [PDF]

Front Allergy
Versteeg SA, Akkerdaas JH, Pařenicová L, Morisset M, Dijk W, O'Malley A, Dommels Y, van Ree R.   +7 more
europepmc   +1 more source

Are interphylum spiralian relationships resolvable? [PDF]

Elife
Serra Silva A, Telford MJ.
europepmc   +1 more source

ADAPT AF-DES and the Limits of Non-inferiority in Long-term Antithrombotic Therapy. [PDF]

Eur Cardiol
Grimaldi M, Rocca B.
europepmc   +1 more source