Results 211 to 220 of about 337,050 (372)

Single‐Cell Analysis Reveals that Vitamin C Inhibits Bone Metastasis of Renal Cancer via Cell Cycle Arrest and Microenvironment Remodeling

Advanced Science, EarlyView.
3D‐cultured renal cancer cells exhibit stem‐like phenotypes and are more efficient in generating bone metastases. Vitamin C treatment can suppress the development of bone metastasis. Single‐cell transcriptomic analysis reveals that vitamin C inhibits metastasis by inducing tumor cell cycle arrest, suppressing osteoclast differentiation, and reducing ...
Jianye Zhang, Qi Zhang, Gang Lin, Ying Wang, Juan Li, Ping Wang, Jie Qi, Yuan Liang, Shiming He, Yanqing Gong, Ninghan Feng, Yang Wang, Yuanyuan Ma, Mei Zhang, Yue Shi, Xuesong Li, Weimin Ci, Liqun Zhou   +17 more
wiley   +1 more source

Identification of PANoptosis-related signature reveals immune infiltration characteristics and immunotherapy responses for renal cell carcinoma

BMC Cancer
PANoptosis is a specific type of inflammatory programmed cell death (PCD) modality that can be involved in three key modes of cellular programmed cell death-pyroptosis, apoptosis and necroptosis. We analyzed PANoptosis activity in three common renal cell
Yan Xu, Jingqi Hua, Hongliang Que, Tengyue Zeng, Quan Li, Junpeng Deng, Jianjun Xie   +6 more
doaj   +1 more source

1291: Prognostic Impact of Cytogenetic Findings in Clear Cell Renal Cell Carcinoma: Improved Survival is Seen in Patients with Loss of Chromosome 3P [PDF]

, 2007
Tobias Klatte, Priya Rao, John S. Lam, Stephen B. Riggs, Nazy Zomorodian, Fairooz F. Kabbinavar, Arie S. Belldegrun, Allan J. Pantuck   +7 more
openalex   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness.

Cancer Cell, 2022
Yize Li, T. Lih, S. Dhanasekaran, R. Mannan, Lijun Chen, M. Cieslik, Yige Wu, Rita Jui-Hsien Lu, D. Clark, Iga Kołodziejczak, R. Hong, Siqi Chen, Yanyan Zhao, Seema Chugh, Wagma Caravan, Nataly Naser Al Deen, Noshad Hosseini, Chelsea J. Newton, Karsten Krug, Yuanwei Xu, Kyung-Cho Cho, Yingwei Hu, Yuping Zhang, Chandan Kumar-Sinha, Weiping Ma, A. Calinawan, Matthew A. Wyczalkowski, M. Wendl, Yuefan Wang, Shenghao Guo, Cissy Zhang, A. Le, Aniket Dagar, A. Hopkins, Hanbyul Cho, F. Leprevost, Xiaojun Jing, Guo Ci Teo, Wenke Liu, M. Reimers, R. Pachynski, A. Lazar, A. Chinnaiyan, B. V. Van Tine, Bing‐yu Zhang, K. Rodland, G. Getz, D. Mani, Pei Wang, F. Chen, G. Hostetter, M. Thiagarajan, W. Linehan, D. Fenyö, S. Jewell, G. Omenn, R. Mehra, M. Wiznerowicz, A. Robles, M. Mesri, Tara Hiltke, E. An, Henry Rodriguez, Daniel W. Chan, C. Ricketts, A. Nesvizhskii, Hui Zhang, Li Ding, Alicia Francis, A. Paulovich, A. Antczak, Anthony Green, A. Colaprico, A. Hakimi, B. Pruetz, B. Hindenach, B. Yadav, B. Reva, Brenda Fevrier-Sullivan, B. Druker, C. Szczylik, C. A. Goldthwaite, Chet Birger, Corbin D. Jones, D. Rohrer, Darlene Tansil, David W. Chesla, David I Heiman, Elizabeth Duffy, Erin Schadt, F. Petralia, G. Bromiński, G. Quiroga-Garza, G. Wilson, Ginny X. Li, Grace Zhao, Y. Hsiao, J. Hsieh, J. Lubiński, Jasmin Bavarva, Jasmine Huang, J. Hafron, J. Eschbacher, Jennifer Hon, Jesse Francis, J. Freymann, Josh N. Vo, Joshua M Wang, J. Kirby, Kakhaber Zaalishvili, K. Ketchum, K. Hoadley, K. S. Um, L. Qi, M. Domagalski, Matt Tobin, Maureen A. Dyer, M. Anurag, M. Borucki, Michael A. Gillette, M. Birrer, M. Ittmann, M. Roehrl, M. Schnaubelt, Michael V. Smith, M. Fam, Nancy V. Roche, Negin Vatanian, Nicollette Maunganidze, O. Potapova, O. Paklina, Pamela VanderKolk, Patricia D. Castro, Paweł Kurzawa, P. Hariharan, Qin Li, Q. K. Li, R. Dhir, Ratna R. Thangudu, Rebecca Montgomery, Richard D. Smith, S. Mareedu, S. Payne, Sandra R. Cerda, S. Cottingham, Sarah Haynes, S. Satpathy, Shannon Richey, Shilpi Singh, S. Tsang, Shuang Cai, Song Cao, S. Gabriel, Steve Carr, T. Liu, Thomas Bauer, Toan Le, X. S. Chen, Xu Zhang, Y. Shutack, Zhen Zhang   +160 more
semanticscholar   +1 more source

Peptide‐Based Biomaterials as a Promising Tool for Cancer Radiotherapy

Advanced Science, EarlyView.
This review provides a systematic overview of peptide‐based biomaterials in tumor radiotherapy, covering their roles as both radiosensitizers and radiopharmaceuticals. Peptide‐based radiosensitizers are generally divided into three categories: peptides as direct radiosensitizers, peptides as carriers of radiosensitizers, and targeted‐peptide‐modified ...
Qian Wang, Xinhui Chu, Jianfeng Liu
wiley   +1 more source

Gender specific expression of tumor suppressor PKCd versus oncogenic PKCn in renal cell carcinoma [PDF]

, 2003
Tumor incidence for renal cell carcinoma is two-fold higher in males than in females. Members of the protein kinase C (PKC) gene family have been shown to be relevant for carcinogenesis.
Brenner, Walburgis, Färber, Gloria, Hengstler, Jan G., Herget, Thomas, Thüroff, Joachim W., Wiesner, Christoph   +5 more
core  

High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma [PDF]

, 2008
Hideyuki Abe, Takao Kamai, Hiromichi Shirataki, Tetsunari Oyama, Kyoko Arai, Ken‐Ichiro Yoshida   +5 more
openalex   +1 more source

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source