Results 231 to 240 of about 337,050 (372)

Complexity of tumor vasculature in clear cell renal cell carcinoma [PDF]

, 2009
Chao‐Nan Qian, Dan Huang, Bill Wondergem, Bin Tean Teh   +3 more
openalex   +1 more source

LncDARS‐AS1 Regulates ATP1A1 Stability and Enhances Na+/K+ ATPase Activity to Promote Osteosarcoma Metastasis

Advanced Science, EarlyView.
This study identifies LncDARS‐AS1 as a novel oncogenic regulator that stabilizes ATP1A1 and enhances Na⁺/K⁺ ATPase activity, promoting osteosarcoma metastasis. Targeting the LncDARS‐AS1/ATP1A1/NKA axis, including pharmacological inhibition with digoxin, offers promising opportunities for the development of new therapeutic strategies against ...
Mingxian Xu, Jiatian Wei, Xiaoyu Feng, Qinkai Zhang, Jian Chen, Xinyue Wang, Xiudan Zhan, Bing Lu, Weitang Guo, Mingzhe Cheng, Renxuan Huang, Shao Xu, Changye Zou   +12 more
wiley   +1 more source

Cytogenetic Profile Predicts Prognosis of Patients With Clear Cell Renal Cell Carcinoma [PDF]

, 2009
Tobias Klatte, Priya Rao, Michela de Martino, Jeffrey C. LaRochelle, Brian Shuch, Nazy Zomorodian, Jonathan W. Said, Fairooz F. Kabbinavar, Arie S. Belldegrun, Allan J. Pantuck   +9 more
openalex   +1 more source

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

Advanced Science, EarlyView.
This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao, Pu Xing, Hao Hao, Jiangbo Chen, Lin Song, Yifan Hou, Xinying Yang, Kai Weng, Jie Chen, Pin Gao, Tongkun Song, Hong Yang, Tianqi Liu, Yumeng Ran, Bo Chen, Wei Zhao, Jiabo Di, Zaozao Wang, Jun Zhang, Xiangqian Su, Beihai Jiang   +20 more
wiley   +1 more source

Immune Checkpoint Inhibitors in Clear Cell Renal Cell Carcinoma (ccRCC). [PDF]

Int J Mol Sci
Rysz J, Ławiński J, Franczyk B, Gluba-Sagr A.   +3 more
europepmc   +1 more source

The PTEN regulator DJ‐1 is associated with hTERT expression in clear cell renal cell carcinoma [PDF]

, 2009
Raviprakash T. Sitaram, Claire J. Cairney, Pawel Grabowski, W. Nicol Keith, Bengt Hallberg, Börje Ljungberg, Göran Roos   +6 more
openalex   +1 more source

SF3A3 Drives Tumorigenesis in Endometrial Cancer by Enhancing c‐FOS Expression and Represents a Potential Therapeutic Target

Advanced Science, EarlyView.
The role of splicing factor 3A subunit 3 (SF3A3) in driving endometrial cancer (EC) progression and potential therapeutic interventions. SF3A3, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), is upregulated in endometrial cancer (EC) and promotes tumor growth and cisplatin resistance. RNA‐binding protein immunoprecipitation (RIP)
Wei Yu, Yi Gu, Hengrui Zhang, Wunan Huang, Lei Sun, Liangjian Ma, Xiaolei Liang, Lexin Liu, Guiping Chen, Weihua Wang, Zhongkai Cao, Xue Li, Xiangjun Chen, Lidan Hu   +13 more
wiley   +1 more source

Proteomics and succinylation modification characterization in clear cell renal cell carcinoma. [PDF]

Discov Oncol
Yue D, Zheng M.
europepmc   +1 more source

Methylation level of the RASSF1A promoter is an independent prognostic factor for clear-cell renal cell carcinoma [PDF]

, 2009
Yosuke Kawai, Shoji Sakano, Yutaka Suehiro, Toshiyuki Okada, Yoshihito Korenaga, Tomohiko Hara, Katsusuke Naito, Hideyasu Matsuyama, Yuji Hinoda   +8 more
openalex   +1 more source

PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Inducing ferroptosis is a promising strategy for combating tumor resistance. Upregulated PIP5K1A competes with NRF2 for KEAP1 binding, which decreases the ubiquitination degradation of NRF2 and promotes its nuclear translocation, thereby suppressing ferroptosis, and ultimately driving hepatocellular carcinoma (HCC) tumorigeneses and sorafenib ...
Mengzhou Guo, Sinuo Chen, Jialei Sun, Ruchen Xu, Zhuoran Qi, Jie Li, Lianer Zhou, Yuan Fang, Tianshu Liu, Jinglin Xia   +9 more
wiley   +1 more source