Results 121 to 130 of about 1,613,704 (299)

Study of blade clearance effects on centrifugal pumps [PDF]

A program of analysis, design, fabrication, and testing has been conducted to develop and experimentally verify analytical models to predict the effects of impeller blade clearance on centrifugal pumps. The effect of tip clearance on pump efficiency, and
Hoshide, R. K., Nielson, C. E.
core   +1 more source

Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial.

, 2012
BACKGROUND: Interferon-gamma (IFNγ) is of key importance in the immune response to Cryptococcus neoformans. Mortality related to cryptococcal meningitis remains high, and novel treatment strategies are needed.
Bekker, Linda-Gail, Bicanic, Tihana, Harrison, Thomas S, Jarvis, Joseph N, Meintjes, Graeme, Rebe, Kevin, Schutz, Charlotte, Williams, Anthony, Williams, Gertrude Ntombomzi, Wood, Robin   +9 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Navier-Stokes analysis of radial turbine rotor performance [PDF]

An analysis of flow through a radial turbine rotor using the three-dimensional, thin-layer Navier-Stokes code RVC3D is described. The rotor is a solid version of an air-cooled metallic radial turbine having thick trailing edges, shroud clearance, and ...
Larosiliere, L. M.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Exploring the Pharmacokinetics of Drugs in Disabled Saudi Patients: A Systematic Review

Pharmaceuticals
Background/Objectives: Disability is a term that involves mental, intellectual, or sensory impairment resulting in the loss of one’s ability to walk or perform the activities necessary to live in a society.
Faleh Alqahtani, Saeed A. Al Awadh, Muhammad Fawad Rasool   +2 more
doaj   +1 more source

A study on the effect of the clearance on the contact stress and kinematics of polymeric composite journal bearings [PDF]

, 2010
In this article the effect of the clearance on the contact stress and kinematics of a polymeric composite journal bearing is investigated. To this purpose a test rig is devised, which is capable to measure the tribological characteristics of the large ...
De Baets, Patrick, Degrieck, Joris, Ost, Wouter, Rezaei, Ali, Van Paepegem, Wim   +4 more
core  

Transient elastohydrodynamic lubrication analysis of a novel metal-on-metal hip prosthesis with a non-spherical femoral bearing surface

, 2011
Effective lubrication performance of metal-on-metal hip implants only requires optimum conformity within the main loaded area, while it is advantageous to increase the clearance in the equatorial region.
Anissian H.L., Bergmann G., Calonius O., Catelas I., Dobbs H.S., Dowson D., Firkins P.J., Gao LM, Grubl A., Hu X.Q., Jacobs J.J., Lee R., Liu F., Meng Q.E., Meng QE, Rieker C., Skipor A.K., Tuke M.A., Venner C.H., Wang F.C., Yao J.Q.   +20 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Silent clearance [PDF]

Nature Immunology, 2017
openaire   +2 more sources