Results 111 to 120 of about 928,462 (307)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
, 2012 A presentation by Tim Bowen and Karen Melanson of the Copyright Clearance Center.Archived web contentSUNY BrockportGiving and Getting Access to Scholarly and Instructional ...
Melanson, Karen, Bowen, Tim
core
Applications of Lyapunov-based analysis techniques for clearance
, 2012 This chapter presents results obtained by applying the Lyapunov-based robustness analysis techniques developed in Chapter 9 to two clearance problems: aeroelastic stability and un-piloted stability. The considered techniques have been employed to certify
Alfio Masi +7 more
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Predicting impact conditions due to bearing clearances in linkage mechanisms.
, 1978 PhDClearances at connections of mechanical systems may allow contact to be momentarily lost between the interconnected elements resulting in impact loading, the generation of noise and deterioration of the bearing surfaces.
Kiliçay, Ö
core
Maximum ingestion and maximum clearance rate of Thalia democratica determined experimentally
, 2014 Maximum ingestion and maximum clearance rate of Thalia democratica determined ...
Don Deibel (8009006), Deibel, Don
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Exploring the Pharmacokinetics of Drugs in Disabled Saudi Patients: A Systematic Review
PharmaceuticalsBackground/Objectives: Disability is a term that involves mental, intellectual, or sensory impairment resulting in the loss of one’s ability to walk or perform the activities necessary to live in a society.
Faleh Alqahtani +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source