Results 121 to 130 of about 1,050,002 (298)
Challenges in the Evolving CME Landscape
Journal of European CME, 2020 Darren Gillgrass
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Relative contributions to toe clearance.
, 2014 Cohen's effect size for factorial ANOVA.†significant statistical interaction (group × joint) and the location of effect revealed upon post-hoc testing.TC: toe clearance.TCmin: minimal toe clearance.Data are mean (sd).
Carolynn Patten (645959) +2 more
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FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Influence of saw blade clearance over the workpiece on tool-wear
Drvna Industrija, 2008 This paper presents the results of experimental measurement of tool-wear in the cutting process with circular saw of oak wood depending on the upper clearance of 5mmand 50 mm, respectively.
Mikuláš Siklienka, Luboš Mišura
doaj
SensorsBackground: Overweight may present an additional challenge when crossing obstacles. More specifically it may affect adequate foot clearance to reduce the risk of obstacle contact.
Matthias Chardon +4 more
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Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Applications of Lyapunov-based analysis techniques for clearance
, 2012 This chapter presents results obtained by applying the Lyapunov-based robustness analysis techniques developed in Chapter 9 to two clearance problems: aeroelastic stability and un-piloted stability. The considered techniques have been employed to certify
Alfio Masi +7 more
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source