Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance imaging [PDF]
Scientific Reports, 2023 Hyperpolarized carbon-13 magnetic resonance imaging is a promising technique for in vivo metabolic interrogation of alterations between health and disease.
James T. Grist +11 more
doaj +2 more sources
Concepts of Lactate Metabolic Clearance Rate and Lactate Clamp for Metabolic Inquiry: A Mini-Review [PDF]
Nutrients, 2023 Laurent A Messonnier +1 more
exaly +2 more sources
Glucose driven bacterial persistence in extensively drug-resistant tuberculosis with diabetes [PDF]
Frontiers in Public HealthBackgroundDiabetes mellitus (DM) disrupts the metabolic environment of extensively drug-resistant tuberculosis (XDR) patients, promoting mycobacterial persistence. Key factors influencing bacterial clearance remain unclear.
Xin Yao +11 more
doaj +2 more sources
Obesity and anesthetic pharmacology: simulation of target-controlled infusion models of propofol and remifentanil [PDF]
Korean Journal of Anesthesiology, 2021 The prevalence of obesity is increasing, resulting in an increase in the number of surgeries performed to treat obesity and diseases induced by obesity. The associated comorbidities as well as the pharmacokinetic and pharmacodynamic changes that occur in
Tae Kyun Kim
doaj +1 more source
Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs. [PDF]
PLoS ONE, 2018 Two chemotypes were examined in vitro with CYPs 3A4 and 2C19 by molecular docking, metabolic profiles, and intrinsic clearance deuterium isotope effects with specifically deuterated form to assess the potential for enhancement of pharmacokinetic ...
Hao Sun +8 more
doaj +1 more source
Biomedicines, 2021 Background: Decreased insulin clearance could be a relatively upstream abnormality in obesity, metabolic syndrome, and nonalcoholic fatty liver disease. Previous studies have shown that sodium-glucose cotransporter 2 inhibitor (SGLT2i) increases insulin ...
Motonori Sato +13 more
doaj +1 more source
Determination of the delivered hemodialysis dose using standard methods and on-line clearance monitoring [PDF]
Vojnosanitetski Pregled, 2006 Background/aim: Delivered dialysis dose has a cumulative effect and significant influence upon the adequacy of dialysis, quality of life and development of co-morbidity at patients on dialysis.
Vlatković Vlastimir +1 more
doaj +1 more source
Frontiers in Marine Science, 2020 The aim of this study was to ascertain if the capacity for acute and chronic compensation of thermal effects on physiological rates represents a trait contributing to inter-individual growth rate differences in the mussel Mytilus galloprovincialis ...
Daniel Prieto +5 more
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Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate. [PDF]
PLoS ONE, 2011 AIMS/HYPOTHESIS: Bile acid sequestrants (BAS) reduce plasma glucose levels in type II diabetics and in murine models of diabetes but the mechanism herein is unknown.
Maxi Meissner +9 more
doaj +1 more source
Insulin Clearance Is Associated with Hepatic Lipase Activity and Lipid and Adiposity Traits in Mexican Americans. [PDF]
PLoS ONE, 2016 Reduction in insulin clearance plays an important role in the compensatory response to insulin resistance. Given the importance of this trait to the pathogenesis of diabetes, a deeper understanding of its regulation is warranted. Our goal was to identify
Artak Labadzhyan +7 more
doaj +1 more source