Results 11 to 20 of about 182,790 (263)

Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice

Scientific Reports, 2023
Obesity affects millions of people worldwide and is associated with an increased risk of cognitive decline. The glymphatic system is a brain-wide metabolic waste clearance system, dysfunction of which is linked to dementia.
Christine Delle, Neža Cankar, Christian Digebjerg Holgersson, Helle Hvorup Knudsen, Elise Schiøler Nielsen, Celia Kjaerby, Yuki Mori, Maiken Nedergaard, Pia Weikop   +8 more
doaj   +1 more source

Metabolic Clearance and Production Rates of Human Thyrotropin [PDF]

Journal of Clinical Investigation, 1974
Metabolic clearance (MCR) and production rates (PR) of human thyrotropin (hTSH) were determined by the constant infusion to equilibrium method 57 times in 55 patients. 16 control patients had a mean hTSH MCR of 50.7 ml/min. The mean hTSH MCR was significantly (P < 0.02) higher in 19 euthyroid men (51.6 ml/min) than in 12 euthyroid women (43.0 ml/min ...
E C, Ridgway, B D, Weintraub, F, Maloof
openaire   +2 more sources

Effect of Acute Thermal Stress Exposure on Ecophysiological Traits of the Mediterranean Sponge Chondrilla nucula: Implications for Climate Change

Biology, 2023
As a result of climate change, the Mediterranean Sea has been exposed to an increase in the frequency and intensity of marine heat waves in the last decades, some of which caused mass mortality events of benthic invertebrates, including sponges.
Mar Bosch-Belmar, Martina Milanese, Antonio Sarà, Valeria Mobilia, Gianluca Sarà   +4 more
doaj   +1 more source

Decreased maximal cortisol secretion rate in patients with cirrhosis: Relation to disease severity

JHEP Reports, 2021
Background & Aims: Hepatic enzymes play a major role in the metabolic elimination of cortisol, and reduced rates of cortisol clearance have been consistently observed in patients with chronic liver disease.
Christina M. Lovato, Thierry Thévenot, Sophie Borot, Vincent Di Martino, Clifford R. Qualls, Frank K. Urban, III, Richard I. Dorin   +6 more
doaj   +1 more source

Metabolic clearance rate and production rate of calcitriol in uremia

Kidney International, 1989
We have previously demonstrated that while both normal humans and dogs tightly control serum calcitriol levels after 25(OH)D administration, anephric humans and 5/6 nephrectomized dogs significantly increase circulating 1,25(OH)2D when supraphysiological concentrations of 25(OH)D are reached in serum.
Dusso, Adriana, Lopez-Hilker, Silvia, Lewis-Finch, Jane, Grooms, Patricia, Brown, Alex, Martin, Kevin, Slatopolsky, Eduardo   +6 more
openaire   +2 more sources

Intraoperative lactate level and lactate clearance is associated with long-term mortality in liver transplant recipients [PDF]

Anesthesia and Pain Medicine
Background Hyperlactatemia has been associated with poor outcomes in various clinical settings including liver transplantation (LT). However, the impact of intraoperative lactate levels and lactate clearance on long-term mortality in LT recipients ...
Akira Katayama, Ezeldeen Abuelkasem, Marianne M. Ligon, Yaroslava Longhitano, David W. Wang   +4 more
doaj   +1 more source

Measuring the Pharmacokinetic Properties of Drugs with a Novel Surgical Rat Model

Journal of Investigative Surgery, 2017
Purpose/aim of the study: The pharmacokinetic (PK) parameters in animal models can help optimize novel candidate drugs prior to human trials. However, due to the complexity of pharmacokinetic experiments, their use is limited in academia.
Ioannis Christakis, Rebecca Scott, James Minnion, Joyceline Cuenco, Tricia Tan, Fausto Palazzo, Stephen Bloom   +6 more
doaj   +1 more source

Population pharmacokinetic analysis of enrofloxacin and its active metabolite ciprofloxacin after intravenous injection to cats with reduced kidney function

Journal of Veterinary Internal Medicine, 2023
Background It is unknown if enrofloxacin accumulates in plasma of cats with reduced kidney function. Hypothesis To determine if enrofloxacin and its active metabolite ciprofloxacin have reduced clearance in azotemic cats.
Jonathan D. Foster, Mahmoud Abouraya, Mark G. Papich, Nancy A. Muma   +3 more
doaj   +1 more source

Establishment of the Protocol of Intramuscular 223RaCl2 Injection and the Corresponding Evaluation on Feasibility and Safety

Journal of Isotopes, 2023
223RaCl2 injection for bone metastasis of prostate cancer has been approved for clinical marketing and achieved good clinical effects. However, there are some defects to be solved in the actual use process. Changing the route of drug administration is an
LI Xiaohong;ZUO Changjing;LI Xiao
doaj   +1 more source

Metabolic clearance rate of radioiodinated human calcitonin in man [PDF]

Journal of Clinical Investigation, 1970
The characteristics of the disappearance of radioiodinated synthetic human calcitonin from plasma have been studied in man. After single injection the disappearance curve was multiexponential. The number of exponentials of the theoretical curve fitting the best with the experimental data varied individually. Metabolic clearance rate was determined both
R, Ardaillou, P, Sizonenko, A, Meyrier, G, Vallée, C, Beaugas   +4 more
openaire   +2 more sources