Results 31 to 40 of about 183,054 (260)

Metabolic clearance and production rates of human growth hormone [PDF]

Journal of Clinical Investigation, 1969
The metabolic clearance rate (MCR) of human growth hormone (HGH) was determined by the constant infusion to equilibrium technique utilizing HGH-(125)I. 22 control subjects had a MCR of 229 +/-52 ml/min (mean +/-SD). No difference was evident between sexes, or between various age groups. Patients with acromegaly demonstrated normal MCR's.
A L, Taylor, J L, Finster, D H, Mintz
openaire   +2 more sources

Pharmacokinetic study on the interaction between succinic acid and irbesartan in rats and its potential mechanism

Pharmaceutical Biology, 2021
Context Succinic acid and irbesartan are commonly used drugs in cardiovascular disease treatment. The interaction might occur during their co-administration, which was still unclear.
Yongpeng Wang, Ruping Rui, Xiaoyan Zhang, Bin Sun   +3 more
doaj   +1 more source

Concentrically Encapsulated Dual-Enzyme Capsules for Synergistic Metabolic Disorder Redressing and Cytotoxic Intermediates Scavenging

Nanomaterials, 2022
Enzyme therapy has important implications for the treatment of metabolic disorders and biological detoxification. It remains challenging to prepare enzymatic nanoreactors with high therapeutic efficiency and low emission of cytotoxic reaction ...
Chao Deng, Xianghai Li, Qianru Jin, Deliang Yi   +3 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

The role of brown adipose tissue in branched-chain amino acid clearance in people

iScience
Summary: Brown adipose tissue (BAT) in rodents appears to be an important tissue for the clearance of plasma branched-chain amino acids (BCAAs) contributing to improved metabolic health.
Yasser G. Abdelhafez, Guobao Wang, Siqi Li, Vanessa Pellegrinelli, Abhijit J. Chaudhari, Anthony Ramirez, Fatma Sen, Antonio Vidal-Puig, Labros S. Sidossis, Samuel Klein, Ramsey D. Badawi, Maria Chondronikola   +11 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity

Nature Communications
Our brain is bathed in cerebrospinal fluid (CSF) that is produced by the choroid plexus. CSF serves as a dispersion route for hormones and nutrients, and a conduit for waste clearance.
Sara D. Lolansen, Eszter O. Révész, Søren N. Andreassen, Marleen Trapp, Chiara Salio, Marco Sassoé-Pognetto, Jens Velde Andersen, Emil W. Westi, Trine L. Toft-Bertelsen, Jonathan H. Wardman, Anne-Kristine Meinild Lundby, Flemming Dela, Annarita Patrizi, Blanca I. Aldana, Nanna MacAulay   +14 more
doaj   +1 more source

Brain Fluid Clearance After Traumatic Brain Injury Measured Using Dynamic Positron Emission Tomography

Neurotrauma Reports
Brain fluid clearance by pathways including the recently described paravascular glymphatic system is a critical homeostatic mechanism by which metabolic products, toxins, and other wastes are removed from the brain.
Tracy Butler, Julia Schubert, Nikolaos A. Karakatsanis, Xiuyuan Hugh Wang, Ke Xi, Yeona Kang, Kewei Chen, Liangdong Zhou, Edward K. Fung, Abigail Patchell, Abhishek Jaywant, Yi Li, Gloria Chiang, Lidia Glodzik, Henry Rusinek, Mony de Leon, Federico Turkheimer, Sudhin A. Shah   +17 more
doaj   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source