Results 51 to 60 of about 183,054 (260)
Biotransformation and kinetics of selected benzimidazole synthetic opioids in human hepatocytes
Frontiers in PharmacologyBackground/ObjectivesThe reemergence of 2-benzylbenzimidazole opioids, also called nitazenes, in the illicit drug market constitutes a serious threat to public health. One of the major challenges in handling exposures and managing intoxications in humans
Gajanan R. Jadhav, Pius S. Fasinu
doaj +1 more source
Combined Effects of Temperature and Seston Concentration on the Physiological Energetics of the Manila Clam Ruditapes philippinarum. [PDF]
PLoS ONE, 2016 The suspension-feeding Manila clam Ruditapes philippinarum is a native species of the western Pacific that is now widely distributed around the globe because of its commercial importance.
Hee Yoon Kang +5 more
doaj +1 more source
Metabolic clearance and production rates of prolactin in man. [PDF]
Journal of Clinical Investigation, 1979 Metabolic clearance rates (MCR) and production rates (PR) of prolactin (PRL) have been determined by the constant infusion to equilibrium technique in 11 normal subjects, 6 patients with hyperthyroidism, 4 patients with hypothyroidism, and 9 patients with hyperprolactinemia. PRL MCR was also determined tin four patients during dopamine infusion.
D S, Cooper +4 more
openaire +2 more sources
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
JGH Open, 2020 Background and Aim The impact of hepatitis C virus (HCV) clearance by direct‐acting antiviral agents (DAAs) on HCV‐related extrahepatic manifestations is not well known.
Riccardo Nevola +8 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Metabolic Clearance Rates, Production Rates and Concentrations of Progesterone in Pregnant Rhesus Monkeys [PDF]
Biology of Reproduction, 1977 It has been reported of rhesus monkeys that uterine vein levels of progesterone decrease by 75% during the 2nd half of pregnancy while maternal peripheral vein levels remain fairly constant. Whether this difference could be explained by declining placental and/or ovarian progesterone production rates (PRs) occurring along with declining metabolic ...
R B, Thau, J T, Lanman, A O, Brinson
openaire +2 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source