Results 41 to 50 of about 182,790 (263)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Lactate clearance predicts outcome after major trauma
African Journal of Emergency Medicine, 2014 To determine a correlation between lactate clearance within 48 h and survival in trauma patients at a Level I trauma centre in a developing country and compare to previous international lactate clearance studies.
Essi Heinonen +3 more
doaj +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Genetic-Based Population Pharmacokinetic Study of Risperidone in Patients with Schizophrenia
Neuropharmacology and TherapyBackground: Individual differences in the blood concentrations of risperidone and its active metabolites affect efficacy and adverse reactions in patients with schizophrenia.
Xiujia Sun +9 more
doaj +1 more source
npj Systems Biology and Applications, 2021 Mucins are present in mucosal membranes throughout the body and play a key role in the microbe clearance and infection prevention. Understanding the metabolic responses of pathogens to mucins will further enable the development of protective approaches ...
Dawson D. Payne +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
PharmaceuticalsBackground/Objectives: Chemical and metabolic kinetics have historically been derived from mass balance differential equations expressed in terms of amounts, and this framework was later extended to pharmacokinetics by converting amount-based equations ...
Leslie Z. Benet, Jasleen K. Sodhi
doaj +1 more source
Combined Effects of Temperature and Seston Concentration on the Physiological Energetics of the Manila Clam Ruditapes philippinarum. [PDF]
PLoS ONE, 2016 The suspension-feeding Manila clam Ruditapes philippinarum is a native species of the western Pacific that is now widely distributed around the globe because of its commercial importance.
Hee Yoon Kang +5 more
doaj +1 more source
Cells, 2022 Energy homeostasis in the central nervous system largely depends on astrocytes, which provide metabolic support and protection to neurons. Astrocytes also ensure the clearance of extracellular glutamate through high-affinity transporters, which ...
Inês Belo do Nascimento +7 more
doaj +1 more source