Results 21 to 30 of about 182,790 (263)

A Novel Method for Predicting the Human Inherent Clearance and Its Application in the Study of the Pharmacokinetics and Drug–Drug Interaction between Azidothymidine and Fluconazole Mediated by UGT Enzyme

Pharmaceutics, 2021
In order to improve the benefit–risk ratio of pharmacokinetic (PK) research in the early development of new drugs, in silico and in vitro methods were constructed and improved.
Yawen Yuan, Jun Zhang, Boyu Fang, Xiaoqiang Xiang, Guo Ma, Shunguo Zhang, Bin Zhu, Weimin Cai   +7 more
doaj   +1 more source

Metabolic Clearance Rate of Oxytocin in Human Subjects

Folia Endocrinologica Japonica, 1989
Oxytocin metabolism seems to occur mainly in the kidney and the liver. Placental cystine amino peptidase (CAP), which inactivates oxytocin by cleavage of the bond between the N-terminal cystine residue and adjacent tyrosine, rises progressively with advancing gestation. The role of CAP in oxytocin metabolism is not clear.
TAKEDA, Satoru, KUWABARA, Yoshinori, MIZUNO, Masahiko   +2 more
openaire   +3 more sources

Aging-Related Alterations of Glymphatic Transport in Rat: In vivo Magnetic Resonance Imaging and Kinetic Study

Frontiers in Aging Neuroscience, 2022
ObjectiveImpaired glymphatic waste clearance function during brain aging leads to the accumulation of metabolic waste and neurotoxic proteins (e.g., amyloid-β, tau) which contribute to neurological disorders.
Lian Li, Guangliang Ding, Li Zhang, Esmaeil Davoodi-Bojd, Michael Chopp, Michael Chopp, Qingjiang Li, Zheng Gang Zhang, Quan Jiang   +8 more
doaj   +1 more source

A study of estrogen metabolic clearance rates and transfer factors [PDF]

Journal of Clinical Investigation, 1969
We have attempted to measure the metabolic clearance rates (MCR) and the transfer factors of estradiol (E(2)) and estrone (E(1)) during 2-hr and 12-hr infusions. When estradiol-(3)H was infused for 2 hr, apparent equilibrium was reached at 70 min; the 12-hr infusions showed that plasma estradiol-(3)H levels increased slowly throughout the infusion ...
W C, Hembree, C W, Bardin, M B, Lipsett
openaire   +2 more sources

Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.

PLoS Biology, 2019
Beiging of white adipose tissue (WAT) is a particularly appealing target for therapeutics in the treatment of metabolic diseases through norepinephrine (NE)-mediated signaling pathways.
Wenxin Song, Qi Luo, Yuping Zhang, Linkang Zhou, Ye Liu, Zhilong Ma, Jianan Guo, Yuedong Huang, Lili Cheng, Ziyi Meng, Zicheng Li, Bin Zhang, Siqi Li, Sook Wah Yee, Hao Fan, Peng Li, Kathleen M Giacomini, Ligong Chen   +17 more
doaj   +1 more source

Population pharmacokinetic model with time‐varying clearance for lorlatinib using pooled data from patients with non‐small cell lung cancer and healthy participants

CPT: Pharmacometrics & Systems Pharmacology, 2021
Lorlatinib, a selective inhibitor of anaplastic lymphoma kinase (ALK) and c‐ROS oncogene 1 (ROS1) tyrosine kinase, is indicated for the treatment of ALK‐positive metastatic non‐small cell lung cancer (NSCLC) following progression on crizotinib and at ...
Joseph Chen, Brett Houk, Yazdi K. Pithavala, Ana Ruiz‐Garcia   +3 more
doaj   +1 more source

Clearance tests to assess liver function state of animals using compounds with high hepatic metabolism [PDF]

E3S Web of Conferences
The article is devoted to the study of the medicinal substances metabolism in the liver and the possibility of using clearance tests with lidocaine and caffeine in veterinary medicine. It has been established that liver is the main organ where metabolism
Ponamarev Vladimir, Popova Olga, Kostrova Anastasia, Agafonova Ludmila   +3 more
doaj   +1 more source

Apolipoprotein E content of VLDL limits LPL-mediated triglyceride hydrolysis

Journal of Lipid Research, 2022
High levels of circulating triglycerides (TGs), or hypertriglyceridemia, are key components of metabolic diseases, such as type 2 diabetes, metabolic syndrome, and CVD.
Brynne E. Whitacre, Philip Howles, Scott Street, Jamie Morris, Debi Swertfeger, W. Sean Davidson   +5 more
doaj   +1 more source

Concentrically Encapsulated Dual-Enzyme Capsules for Synergistic Metabolic Disorder Redressing and Cytotoxic Intermediates Scavenging

Nanomaterials, 2022
Enzyme therapy has important implications for the treatment of metabolic disorders and biological detoxification. It remains challenging to prepare enzymatic nanoreactors with high therapeutic efficiency and low emission of cytotoxic reaction ...
Chao Deng, Xianghai Li, Qianru Jin, Deliang Yi   +3 more
doaj   +1 more source

Metabolic clearance and production rates of human growth hormone [PDF]

Journal of Clinical Investigation, 1969
The metabolic clearance rate (MCR) of human growth hormone (HGH) was determined by the constant infusion to equilibrium technique utilizing HGH-(125)I. 22 control subjects had a MCR of 229 +/-52 ml/min (mean +/-SD). No difference was evident between sexes, or between various age groups. Patients with acromegaly demonstrated normal MCR's.
A L, Taylor, J L, Finster, D H, Mintz
openaire   +2 more sources