Results 21 to 30 of about 197,495 (263)

Metabolic clearance and production rates of human growth hormone [PDF]

Journal of Clinical Investigation, 1969
The metabolic clearance rate (MCR) of human growth hormone (HGH) was determined by the constant infusion to equilibrium technique utilizing HGH-(125)I. 22 control subjects had a MCR of 229 +/-52 ml/min (mean +/-SD). No difference was evident between sexes, or between various age groups. Patients with acromegaly demonstrated normal MCR's.
A L, Taylor, J L, Finster, D H, Mintz
openaire   +2 more sources

Establishment of the Protocol of Intramuscular 223RaCl2 Injection and the Corresponding Evaluation on Feasibility and Safety

Journal of Isotopes, 2023
223RaCl2 injection for bone metastasis of prostate cancer has been approved for clinical marketing and achieved good clinical effects. However, there are some defects to be solved in the actual use process. Changing the route of drug administration is an
LI Xiaohong;ZUO Changjing;LI Xiao
doaj   +1 more source

A Novel Method for Predicting the Human Inherent Clearance and Its Application in the Study of the Pharmacokinetics and Drug–Drug Interaction between Azidothymidine and Fluconazole Mediated by UGT Enzyme

Pharmaceutics, 2021
In order to improve the benefit–risk ratio of pharmacokinetic (PK) research in the early development of new drugs, in silico and in vitro methods were constructed and improved.
Yawen Yuan, Jun Zhang, Boyu Fang, Xiaoqiang Xiang, Guo Ma, Shunguo Zhang, Bin Zhu, Weimin Cai   +7 more
doaj   +1 more source

Pharmacokinetics-based analysis of indomethacin’s anti-tumor effect and drug efficacy

Pakistan Journal of Pharmaceutical Sciences, 2020
Non-steroidal anti-inflammatory drugs are commonly used anti-inflammatory analgesics in clinic. Indomethacin is a kind of NSAIDs and has anti-tumor effect. It can significantly change the growth cycle of cancer cells, inhibit their proliferation. In this
Zhang Yan, Zhang Jun, Zhao Zhu, Gao Jingjing, Li Ke Jinan, China   +5 more
doaj   +1 more source

A study of estrogen metabolic clearance rates and transfer factors [PDF]

Journal of Clinical Investigation, 1969
We have attempted to measure the metabolic clearance rates (MCR) and the transfer factors of estradiol (E(2)) and estrone (E(1)) during 2-hr and 12-hr infusions. When estradiol-(3)H was infused for 2 hr, apparent equilibrium was reached at 70 min; the 12-hr infusions showed that plasma estradiol-(3)H levels increased slowly throughout the infusion ...
W C, Hembree, C W, Bardin, M B, Lipsett
openaire   +2 more sources

Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.

PLoS Biology, 2019
Beiging of white adipose tissue (WAT) is a particularly appealing target for therapeutics in the treatment of metabolic diseases through norepinephrine (NE)-mediated signaling pathways.
Wenxin Song, Qi Luo, Yuping Zhang, Linkang Zhou, Ye Liu, Zhilong Ma, Jianan Guo, Yuedong Huang, Lili Cheng, Ziyi Meng, Zicheng Li, Bin Zhang, Siqi Li, Sook Wah Yee, Hao Fan, Peng Li, Kathleen M Giacomini, Ligong Chen   +17 more
doaj   +1 more source

Aging-Related Alterations of Glymphatic Transport in Rat: In vivo Magnetic Resonance Imaging and Kinetic Study

Frontiers in Aging Neuroscience, 2022
ObjectiveImpaired glymphatic waste clearance function during brain aging leads to the accumulation of metabolic waste and neurotoxic proteins (e.g., amyloid-β, tau) which contribute to neurological disorders.
Lian Li, Guangliang Ding, Li Zhang, Esmaeil Davoodi-Bojd, Michael Chopp, Michael Chopp, Qingjiang Li, Zheng Gang Zhang, Quan Jiang   +8 more
doaj   +1 more source

Clearance tests to assess liver function state of animals using compounds with high hepatic metabolism [PDF]

E3S Web of Conferences
The article is devoted to the study of the medicinal substances metabolism in the liver and the possibility of using clearance tests with lidocaine and caffeine in veterinary medicine. It has been established that liver is the main organ where metabolism
Ponamarev Vladimir, Popova Olga, Kostrova Anastasia, Agafonova Ludmila   +3 more
doaj   +1 more source

Population pharmacokinetic model with time‐varying clearance for lorlatinib using pooled data from patients with non‐small cell lung cancer and healthy participants

CPT: Pharmacometrics & Systems Pharmacology, 2021
Lorlatinib, a selective inhibitor of anaplastic lymphoma kinase (ALK) and c‐ROS oncogene 1 (ROS1) tyrosine kinase, is indicated for the treatment of ALK‐positive metastatic non‐small cell lung cancer (NSCLC) following progression on crizotinib and at ...
Joseph Chen, Brett Houk, Yazdi K. Pithavala, Ana Ruiz‐Garcia   +3 more
doaj   +1 more source

Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess, Gustaf Glavå, Simon Skau, Hans‐Georg Kuhn, Maria Bäck, Marianne Jarfelt   +5 more
wiley   +1 more source