Results 191 to 200 of about 783,748 (258)

Linking biomimetic binding measurements to pharmacokinetic models of volume of distribution and hepatic clearance. [PDF]

ADMET DMPK
Valko K.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Amyloid-<i>β</i> clearance: an astrocytic perspective. [PDF]

Front Neurosci
Li J, Lv Z, Chen X, Fu F, Yang K, Lai G, Wu H, Xie G.   +7 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets. [PDF]

Mol Biomed
Wang NN, Liu ZJ, Wang Y, Cao F, Xu D.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The signaling and regulatory functions of dying cells and cell corpses. [PDF]

Commun Biol
Zhang G, Liu J, Li W, Wang B, Feng H, Cui T, Pan T, Chen D, Xiong Y.   +8 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Deciphering the Neuroautophagic Interactome: Molecular Circuits Linking Selective Autophagy to Neuropathological Cascades in Neurological Disorders. [PDF]

Int J Biol Sci
Luo P, Travis ZD, Lenahan C, Wu H, Zhang J, Yu J, Xu W.   +6 more
europepmc   +1 more source

The Influence of Athlete-Specific Factors on Time to Return to Sport Clearance Following Hip Arthroscopy for Femoroacetabular Impingement Syndrome in Division I Collegiate Athletes. [PDF]

Orthop J Sports Med
Kuik ML, Blomquist MB, Knurr KA, Spiker AM.   +3 more
europepmc   +1 more source