Results 281 to 290 of about 1,663,252 (327)

The liver as a metabolic and immune hub in Alzheimer's disease: From mechanisms to therapeutic opportunities. [PDF]

J Prev Alzheimers Dis
Chen J, Wang L, Zhou Y, Zhao S, Chen Q, Zheng K.   +5 more
europepmc   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Modeling Metabolite Kinetics with a Partial Differential Equation-Based Hepatic Sinusoidal Model and MALDI-Mass Spectrometry Imaging of Verapamil and Its Metabolites. [PDF]

J Med Chem
Parise RJ, Chen B, Gibson CR, Cancilla MT, Nagar S, Korzekwa K.   +5 more
europepmc   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Population pharmacokinetics of tofacitinib in patients with active ankylosing spondylitis. [PDF]

Int J Clin Pharmacol Ther
Tsuchiwata S, Suzuki A, Wang Q, Kanik K, Fallon L, Menon S.   +5 more
europepmc   +1 more source

Linking human cerebral and ocular waste clearance: Insights from tear fluid and ultra-high field MRI

Merel M. van der Thiel, Nienke van de Sande, Anouk Meeusen, Gerhard S. Drenthen, Alida A. Postma, Rudy M.M.A. Nuijts, Noa van der Knaap, Inez H.G.B. Ramakers, Carroll A.B. Webers, Walter H. Backes, Marlies Gijs, Jacobus F.A. Jansen   +11 more
openalex   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants. [PDF]

Clin Transl Sci
Kim JD, Metzger IF, Lu JBL, Skaar TC, Desta Z.   +4 more
europepmc   +1 more source

The long walk to a short half-life: the discovery of augmented renal clearance and its impact on antibiotic dosing. [PDF]

J Antimicrob Chemother
Lipman J, Lewis RE.
europepmc   +1 more source

The glymphatic system in neurodegenerative diseases and brain tumors: mechanistic insights, biomarker advances, and therapeutic opportunities. [PDF]

Acta Neuropathol Commun
Jia L, Chen Y, Li H, Zhao K, Ge S, Wang C, Zhao J, Li F, Zhang L, Yao A.   +9 more
europepmc   +1 more source