Results 21 to 30 of about 1,602,450 (278)

Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization

Nature Communications, 2019
Izumo and Juno are receptors on sperm and eggs respectively required for fusion, but other factors for sperm-egg fusion are poorly studied. Here, the authors report that phosphatidylserine, found mainly on cells marked for death, is also present on ...
Claudia M. Rival, Wenhao Xu, Laura S. Shankman, Sho Morioka, Sanja Arandjelovic, Chang Sup Lee, Karen M. Wheeler, Ryan P. Smith, Lisa B. Haney, Brant E. Isakson, Scott Purcell, Jeffrey J. Lysiak, Kodi S. Ravichandran   +12 more
doaj   +1 more source

Human FSH Glycoform α-Subunit Asparagine52 Glycans: Major Glycan Structural Consistency, Minor Glycan Variation in Abundance

Frontiers in Endocrinology, 2022
Follicle-stimulating hormone (FSH), an α/β heterodimeric glycoprotein hormone, consists of functionally significant variants resulting from the presence or absence of either one of two FSHβ subunit N-glycans.
Viktor Y. Butnev, Jeffrey V. May, Alan R. Brown, Tarak Sharma, Vladimir Y. Butnev, William K. White, David J. Harvey, George R. Bousfield   +7 more
doaj   +1 more source

The development of methodological techniques and an algorithm for diagnosing modern intake systems for internal combustion engines [PDF]

FME Transactions, 2022
Type Diagnosing and detecting malfunctions in internal combustion engines (ICE) is not an easy task due to their complex design. Timely and high-quality ICE monitoring allows performance to be maintained and prevents breakdowns.
Balyasnikov A.S., Gritsenko A., Shepelev V., Kaliyev B.K., Kostyuchenkov N., Fadina O.   +5 more
doaj   +1 more source

Genetic Variation in the IL-6 and HLA-DQB1 Genes Is Associated with Spontaneous Clearance of Hepatitis C Virus Infection. [PDF]

, 2016
Background. Millions of people are infected with hepatitis C virus (HCV) worldwide and 30% spontaneously clear the infection. Reasons for HCV clearance without antiviral treatment are not well understood. Methods.
Belitskaya-Lévy, Ilana, Chary, Aarthi, Holodniy, Mark, Lazzeroni, Laura C, Monto, Alexander, Ryan, James, Waldron, Paul Ravi, Winters, Mark, Won, Johann   +8 more
core   +3 more sources

A Simple Method for the Prediction of Therapeutic Proteins (Monoclonal and Polyclonal Antibodies and Non-Antibody Proteins) for First-in-Pediatric Dose Selection: Application of Salisbury Rule

Antibodies, 2022
In order to conduct a pediatric clinical trial, it is important to optimize pediatric dose as accurately as possible. In this study, a simple weight-based method known as ‘Salisbury Rule’ was used to predict pediatric dose for therapeutic proteins and ...
Iftekhar Mahmood
doaj   +1 more source

Deformation analysis of the main components in a single Screw compressor [PDF]

, 2015
The single screw compressor is used in many fields such as air compression, chemical industry and refrigeration. During operation, different gas pressures and temperatures applied on the components can cause different degrees of deformation, which leads ...
De Paepe, Michel, Feng, Quanke, Liao, Xueli, Liu, Feilong, van den Broek, Martijn   +4 more
core   +1 more source

Faecal bacteria in Perna perna (Linnaeus, 1758) (Mollusca: Bivalvia) for biomonitoring coastal waters and seafood quality

Brazilian Journal of Oceanography, 2010
Urban development in coastal areas is intense and leads to the increase of sewage outfall and other negative impacts as consequences. Thus, stringent regulations establishing limits to the microbiological contamination of water and seafood are needed ...
Diego Igawa Martinez, Ana Júlia Fernandes Cardoso de Oliveira   +1 more
doaj   +1 more source

Incidence, persistence, and clearance of anogenital human papillomavirus among men who have sex with men in Taiwan: a community cohort study

Frontiers in Immunology, 2023
BackgroundMen who have sex with men (MSM) have an increased risk of human papillomavirus (HPV) infection. This study aimed to assess the incidence, persistence, and clearance of anogenital HPV infections among MSM and the correlates in a 3-year community
Xinyi Zhou, Tian Tian, Zhen Lu, Yi-Fang Yu, Yuwei Li, Yiguo Zhou, Yi-Fan Lin, Carol Strong, Huachun Zou, Huachun Zou   +9 more
doaj   +1 more source

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome [PDF]

, 2009
Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's disease, a neurodegenerative disease associated with aging and the accumulation of mutant Htt in diseased neurons.
Aiken, Ali Khoshnan, Alice L. Lau, Ana Maria Cuervo, Anne, Apostol, Arrasate, Arrasate, Ashish Massey, Atwal, Atwal, Björkqvist, Brown, Charity T. Aiken, Chen, Chondrogianni, Cornett, Cuervo, Cuervo, Cuervo, D'Orazi, Dan, Donald C. Lo, Fang, Finkbeiner, Frank M. LaFerla, Gillian Bates, Graham, Grossman, Gu, Guerrero, Gutekunst, Hasan Khashwji, Henn, Hernandez-Hernandez, Hietakangas, Hofmann, Hu, Huang, Humbert, Hunter, J. Lawrence Marsh, Jacqueline Gire O'Rourke, Jeong, Jiang, Joan S. Steffan, Karin, Karin, Katalin Illes, Kaushik, Kazantsev, Khoshnan, Khoshnan, Kim N. Green, Komatsu, Lan Huang, Leslie Michels Thompson, Linda S. Kaltenbach, Liu, Lo, Luo, Mangiarini, Marta Martinez-Vincente, Martinez-Vicente, Massey, Massey, Michael R. Hayden, Michels, Mizushima, Montserrat Arrasate, Namita Agrawal, Orr, Paul H. Patterson, Peters-Libeu, Rockabrand, Saudou, Schilling, Scott O. Zeitlin, Shao, Southwell, Steffan, Steffan, Steffan, Steven Finkbeiner, Tagwerker, Tamas Lukacsovich, Tonoki, Verma, Walker, Warby, Warby, Warby, Wu, Xia, Ya-Zhen Zhu, Yanai, Zhang, Zuccato   +97 more
core   +3 more sources

The “Cerebrospinal Fluid Sink Therapeutic Strategy” in Alzheimer’s Disease—From Theory to Design of Applied Systems

Biomedicines, 2022
Alzheimer’s disease (AD) is a global health problem, with incidence and prevalence considered to increase during the next decades. However, no currently available effective treatment exists despite numerous clinical trials in progress. Moreover, although
Thomas Gabriel Schreiner, Manuel Menéndez-González, Bogdan Ovidiu Popescu   +2 more
doaj   +1 more source