Results 31 to 40 of about 1,545,869 (342)

Sultiame pharmacokinetic profile in plasma and erythrocytes after single oral doses: A pilot study in healthy volunteers

open access: yesPharmacology Research & Perspectives, 2020
A pilot study was conducted aiming at specifying sultiame's pharmacokinetic profile, completed by in vitro assays evaluating the intraerythrocytic transfer of sultiame and by a pharmacokinetic model assessing its distribution.
Kim Dao   +11 more
doaj   +1 more source

PLANTING OF RAMIN (GONYSTYLUS BANCANUS KURZ) WILDING IN PEAT SWAMP THICKET OF CENTRAL KALIMANTAN [PDF]

open access: yesRussian Journal of Agricultural and Socio-Economic Sciences, 2019
The purpose of this study was to determine the effect of planting row with different widths on the growth of Ramin seedlings planted in the area of peat swamp thicket.
Rahmawati R.
doaj   +1 more source

Genetic Variation in the IL-6 and HLA-DQB1 Genes Is Associated with Spontaneous Clearance of Hepatitis C Virus Infection. [PDF]

open access: yes, 2016
Background. Millions of people are infected with hepatitis C virus (HCV) worldwide and 30% spontaneously clear the infection. Reasons for HCV clearance without antiviral treatment are not well understood. Methods.
Belitskaya-Lévy, Ilana   +8 more
core   +3 more sources

Deformation analysis of the main components in a single Screw compressor [PDF]

open access: yes, 2015
The single screw compressor is used in many fields such as air compression, chemical industry and refrigeration. During operation, different gas pressures and temperatures applied on the components can cause different degrees of deformation, which leads ...
De Paepe, Michel   +4 more
core   +1 more source

Development and Evaluation of Physiologically Based Pharmacokinetic Drug–Disease Models for Predicting Rifampicin Exposure in Tuberculosis and Cirrhosis Populations

open access: yesPharmaceutics, 2019
The physiologically based pharmacokinetic (PBPK) approach facilitates the construction of novel drug−disease models by allowing incorporation of relevant pathophysiological changes.
Muhammad F. Rasool   +7 more
doaj   +1 more source

The “Cerebrospinal Fluid Sink Therapeutic Strategy” in Alzheimer’s Disease—From Theory to Design of Applied Systems

open access: yesBiomedicines, 2022
Alzheimer’s disease (AD) is a global health problem, with incidence and prevalence considered to increase during the next decades. However, no currently available effective treatment exists despite numerous clinical trials in progress. Moreover, although
Thomas Gabriel Schreiner   +2 more
doaj   +1 more source

Liposome Clearance

open access: yesBioscience Reports, 2002
The clearance rate of liposomal drugs from the circulation is determined by the rate and extent of both drug release and uptake of liposomes by cells of the mononuclear phagocyte system (MPS). Intravenously injected liposomes initially come into contact with serum proteins.
Tatsuhiro, Ishida   +2 more
openaire   +2 more sources

Cilia and Mucociliary Clearance [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2016
Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The functional components are the protective mucous layer, the airway surface liquid layer, and the cilia on the surface of ciliated cells. The cilia are specialized organelles that beat in metachronal waves to propel pathogens and inhaled particles trapped in the mucous ...
Ximena M. Bustamante-Marin   +1 more
openaire   +3 more sources

Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition [PDF]

open access: yes, 2017
Accumulation and deposition of amyloid-β (Aβ) in the brain represent an early and perhaps necessary step in the pathogenesis of Alzheimer's disease (AD).
Bu, Guojun   +8 more
core   +2 more sources

A Simple Method for the Prediction of Therapeutic Proteins (Monoclonal and Polyclonal Antibodies and Non-Antibody Proteins) for First-in-Pediatric Dose Selection: Application of Salisbury Rule

open access: yesAntibodies, 2022
In order to conduct a pediatric clinical trial, it is important to optimize pediatric dose as accurately as possible. In this study, a simple weight-based method known as ‘Salisbury Rule’ was used to predict pediatric dose for therapeutic proteins and ...
Iftekhar Mahmood
doaj   +1 more source

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