Results 11 to 20 of about 928,462 (307)

The contribution of apixaban renal clearance to total clearance [PDF]

Journal of Thrombosis and Thrombolysis, 2015
To the Editor, Kreutz [1] reported that the renal clearance of absorbed active apixaban was 50 %. From the references cited, it is assumed that this value was obtained using the reported absolute oral bioavailability of 50 % [2] and data from a human absorption, distribution, metabolism, excretion (ADME) study, in which ~23 % of the radiolabeled ...
Frost, Charles, Boyd, Rebecca A.
openaire   +2 more sources

The incidence of hepatocellular carcinoma and clearance of hepatitis B surface for CHB patients in the indeterminate phase: a systematic review and meta-analysis

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundNearly 30%–40% of patients with chronic hepatitis B do not fall into any of the traditional natural history classification and thus are classified as indeterminate.
Min Liu, Min Liu, Taixue Zhao, Yuting Zhang, A-Mei Zhang, Jiawei Geng, Xueshan Xia, Xueshan Xia   +7 more
doaj   +1 more source

OER: Lessons from the Field

Insights: The UKSG Journal, 2019
As open educational resources (OER) expand in the US and elsewhere, attention should be paid to the challenges of implementing OER and solutions to those challenges.
Roy Kaufman, Andrew Campana
doaj   +1 more source

Influence of Aerodynamic Preloads and Clearance on the Dynamic Performance and Stability Characteristic of the Bump-Type Foil Air Bearing

Machines, 2021
The dry lubricated bump-type foil air bearing enables a carrying load capacity due to a pressure build up in a convergent air film. Since the air bearing provides low power dissipation above the lift-off speed and the flexible foil provides an adaptivity
Fabian Walter, Michael Sinapius
doaj   +1 more source

Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization

Nature Communications, 2019
Izumo and Juno are receptors on sperm and eggs respectively required for fusion, but other factors for sperm-egg fusion are poorly studied. Here, the authors report that phosphatidylserine, found mainly on cells marked for death, is also present on ...
Claudia M. Rival, Wenhao Xu, Laura S. Shankman, Sho Morioka, Sanja Arandjelovic, Chang Sup Lee, Karen M. Wheeler, Ryan P. Smith, Lisa B. Haney, Brant E. Isakson, Scott Purcell, Jeffrey J. Lysiak, Kodi S. Ravichandran   +12 more
doaj   +1 more source

Human FSH Glycoform α-Subunit Asparagine52 Glycans: Major Glycan Structural Consistency, Minor Glycan Variation in Abundance

Frontiers in Endocrinology, 2022
Follicle-stimulating hormone (FSH), an α/β heterodimeric glycoprotein hormone, consists of functionally significant variants resulting from the presence or absence of either one of two FSHβ subunit N-glycans.
Viktor Y. Butnev, Jeffrey V. May, Alan R. Brown, Tarak Sharma, Vladimir Y. Butnev, William K. White, David J. Harvey, George R. Bousfield   +7 more
doaj   +1 more source

The development of methodological techniques and an algorithm for diagnosing modern intake systems for internal combustion engines [PDF]

FME Transactions, 2022
Type Diagnosing and detecting malfunctions in internal combustion engines (ICE) is not an easy task due to their complex design. Timely and high-quality ICE monitoring allows performance to be maintained and prevents breakdowns.
Balyasnikov A.S., Gritsenko A., Shepelev V., Kaliyev B.K., Kostyuchenkov N., Fadina O.   +5 more
doaj   +1 more source

Liposome Clearance

Bioscience Reports, 2002
The clearance rate of liposomal drugs from the circulation is determined by the rate and extent of both drug release and uptake of liposomes by cells of the mononuclear phagocyte system (MPS). Intravenously injected liposomes initially come into contact with serum proteins.
Tatsuhiro, Ishida, Hideyoshi, Harashima, Hiroshi, Kiwada   +2 more
openaire   +2 more sources

A Simple Method for the Prediction of Therapeutic Proteins (Monoclonal and Polyclonal Antibodies and Non-Antibody Proteins) for First-in-Pediatric Dose Selection: Application of Salisbury Rule

Antibodies, 2022
In order to conduct a pediatric clinical trial, it is important to optimize pediatric dose as accurately as possible. In this study, a simple weight-based method known as ‘Salisbury Rule’ was used to predict pediatric dose for therapeutic proteins and ...
Iftekhar Mahmood
doaj   +1 more source

Faecal bacteria in Perna perna (Linnaeus, 1758) (Mollusca: Bivalvia) for biomonitoring coastal waters and seafood quality

Brazilian Journal of Oceanography, 2010
Urban development in coastal areas is intense and leads to the increase of sewage outfall and other negative impacts as consequences. Thus, stringent regulations establishing limits to the microbiological contamination of water and seafood are needed ...
Diego Igawa Martinez, Ana Júlia Fernandes Cardoso de Oliveira   +1 more
doaj   +1 more source