Results 101 to 110 of about 1,019,266 (298)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

jwatowatson/Determinants-viral-clearance: v1.1

<p>Minor changes on reporting median population viral clearance half-lives.</p ...
psamonwong, James Watson
core   +1 more source

Photodegradable CuS SERS Probes for Intraoperative Residual Tumor Detection, Ablation, and Self-Clearance

, 2019
Surface-enhanced Raman scattering (SERS) probes have exhibited great potential in biomedical applications. However, currently reported SERS probes are mainly fabricated by nondegradable Au or Ag nanostructures, which are not favorably cleared from the ...
Lei Fu (429363), Chenchen Fan (2618161), Xiaohong Fang (529506), Yuanyuan Qiu (3690961), Miao Lin (539712), Gaoxian Chen (4516279), Xiajing Gu (6630533), Shan Cong (1753936), Zeyu Xiao (2121262), Mingwang Li (5613587), Zhigang Zhao (288127)   +10 more
core   +1 more source

Modelling mucociliary clearance [PDF]

, 2008
Mathematical modelling of the fluid mechanics of mucociliary clearance (MCC) is reviewed and future challenges for researchers are discussed. The morphology of the bronchial and tracheal airway surface liquid (ASL) and ciliated epithelium are briefly ...
Gaffney, Eamonn, E.A. Gaffney, Smith, D J, Smith, DJ, J.R. Blake, Smith, David; id_orcid, Gaffney, E, D.J. Smith, Gaffney, E. A., Blake, JR, Blake, J R, Gaffney, EA, Blake, John   +12 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Current understanding of the mechanisms for clearance of apoptotic cells-a fine balance [PDF]

, 2013
Apoptosis is an important cell death mechanism by which multicellular organisms remove unwanted cells. It culminates in a rapid, controlled removal of cell corpses by neighboring or recruited viable cells.
Andrew Devitt, Devitt, Andrew, Hawkins, Lois A., Lois A. Hawkins   +3 more
core   +1 more source

Mannose receptor contributes to preferential oligomannosidic glycoform clearance in a murine pharmacokinetics model

mAbs
The pharmacokinetic profile of therapeutic antibodies, which affects the dosing frequency, efficacy, and cost of the products, is influenced by several molecular features, including N- glycosylation. While the accelerated clearance of antibodies carrying
David Falck, Steinar Gijze, Anna M. Wasynczuk, Sebastian Malik, Aline Tridon, Martin Lechmann, Manfred Wuhrer, Dietmar Reusch   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source