Results 71 to 80 of about 1,613,704 (299)

Development and Evaluation of Physiologically Based Pharmacokinetic Drug–Disease Models for Predicting Rifampicin Exposure in Tuberculosis and Cirrhosis Populations

Pharmaceutics, 2019
The physiologically based pharmacokinetic (PBPK) approach facilitates the construction of novel drug−disease models by allowing incorporation of relevant pathophysiological changes.
Muhammad F. Rasool, Sundus Khalid, Abdul Majeed, Hamid Saeed, Imran Imran, Mohamed Mohany, Salim S. Al-Rejaie, Faleh Alqahtani   +7 more
doaj   +1 more source

Dual clearance squeeze film damper [PDF]

, 1985
A dual clearance hydrodynamic liquid squeeze film damper for a gas turbine engine is described. Under normal operating conditions, the device functions as a conventional squeeze film damper, using only one of its oil films.
Fleming, D. P.
core   +1 more source

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

Phospholipids: Key Players in Apoptosis and Immune Regulation

Molecules, 2009
Phosphatidylserine (PS), a phospholipid predominantly found in the inner leaflet of eukaryotic cellular membranes, plays important roles in many biological processes.
Udo S. Gaipl, Martin Herrmann, Benjamin Frey, Christina Janko, Luis E. Muñoz, Ricardo A. Chaurio   +5 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Phenotyping of CYP3A by Oral Midazolam in Healthy Mazandarani Volunteers (Iran)

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2011
BACKGROUND AND OBJECTIVE: CYP3A is responsible for hepatic microsomal metabolism of more than 50% of drugs which are its specific substrate. Metabolic activity of this enzyme depends on several factors.
MR Shiran, S , Gharooee Ahangar, SH Rostamkolaee, AA Sefidgar, M Baradaran, M Hashemi, M Baleghi, AA Moghadamnia   +7 more
doaj  

Heparin chromatography as an in vitro predictor for antibody clearance rate through pinocytosis

mAbs, 2020
The pharmacokinetic (PK) properties of therapeutic antibodies directly affect efficacy, dose and dose intervals, application route and tissue penetration.
Thomas E. Kraft, Wolfgang F. Richter, Thomas Emrich, Alexander Knaupp, Michaela Schuster, Andreas Wolfert, Hubert Kettenberger   +6 more
doaj   +1 more source

A Principal Components Analysis Approach to Quantifying Foot Clearance and Foot Clearance Variability [PDF]

, 2019
Low foot clearance and high variability may be related to falls risk. Foot clearance is often defined as the local minimum in toe height during swing; however, not all strides have this local minimum.
Barrett, Barrett, Begg, Begg, Begg, Begg, Borg, Borg, Brandon, Brandon, Byju, Byju, Daffertshofer, Daffertshofer, De Asha, De Asha, Khandoker, Khandoker, Little, Little, Loverro, Loverro, Mills, Mills, Moosabhoy, Moosabhoy, Nagano, Nagano, Nagano, Nagano, Robinovitch, Robinovitch, Santhiranayagam, Santhiranayagam, Santhiranayagam, Santhiranayagam, Savin, Savin, Schulz, Schulz, Schulz, Schulz, Senden, Senden, Sullivan, Sullivan, Thies, Thies, Weinhandl, Weinhandl, Winter, Winter, Zeni, Zeni   +53 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

The potential of bacterial anti-phagocytic proteins in suppressing the clearance of extracellular vesicles mediated by host phagocytosis

Frontiers in Immunology
Extracellular vesicles (EVs), characterized by low immunogenicity, high biocompatibility and targeting specificity along with excellent blood-brain barrier permeability, are increasingly recognized as promising drug delivery vehicles for treating a ...
Jiacong Sun, Congcong Chen, Pengpeng Pan, Keyi Zhang, Jinrui Xu, Jinrui Xu, Cheng Chen   +6 more
doaj   +1 more source