Results 71 to 80 of about 928,462 (307)
Phenotyping of CYP3A by Oral Midazolam in Healthy Mazandarani Volunteers (Iran)
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2011 BACKGROUND AND OBJECTIVE: CYP3A is responsible for hepatic microsomal metabolism of more than 50% of drugs which are its specific substrate. Metabolic activity of this enzyme depends on several factors.
MR Shiran +7 more
doaj
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Dynamic behaviour of a vibratory linkage mechanism with bearing clearance.
, 1974 PhDThe work presented involves the theoretical and experimental studies of the kinematic and dynamic effects of bearing clearance in linkage mechanisms.
Wu, C
core
Frontiers in ImmunologyExtracellular vesicles (EVs), characterized by low immunogenicity, high biocompatibility and targeting specificity along with excellent blood-brain barrier permeability, are increasingly recognized as promising drug delivery vehicles for treating a ...
Jiacong Sun +6 more
doaj +1 more source
Pharmaceutics, 2017 Tangeretin (TAN) is a dietary polymethoxylated flavone that possesses a broad scope of pharmacological activities. A simple high-performance liquid chromatography (HPLC) method was developed and validated in this study to quantify TAN in plasma of ...
Mai Gamal Elhennawy, Hai-Shu Lin
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Energies, 2015 Torsional systems with gear pairs such as the gearbox of wind turbines or vehicle driveline systems inherently show impact phenomena due to clearance-type nonlinearities when the system experiences sinusoidal excitation.
Jong-Yun Yoon, Byeongil Kim
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
The value of statistical life and cost-benefit evaluations of landmine clearance in Cambodia
, 2008 Development agencies spend approximately US$400 million per year on landmine clearance. Yet many cost-benefit evaluations suggest that landmine clearance is socially wasteful because costs appear to far outweigh social benefits.
Helmers, Kent +5 more
core
, 2019 Surface-enhanced Raman scattering (SERS) probes have exhibited great potential in biomedical applications. However, currently reported SERS probes are mainly fabricated by nondegradable Au or Ag nanostructures, which are not favorably cleared from the ...
Lei Fu (429363) +10 more
core +1 more source