Results 91 to 100 of about 1,846,891 (255)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Estimated glomerular filtration rate correlates poorly with four-hour creatinine clearance in critically ill patients with acute kidney injury. [PDF]

, 2013
Introduction. RIFLE and AKIN provide a standardised classification of acute kidney injury (AKI), but their categorical rather than continuous nature restricts their use to a research tool. A more accurate real-time description of renal function in AKI is
Iain A. M. MacPhee, Kirwan, CJ, Barbara J. Philips, Christopher J. Kirwan, Philips, BJ, Macphee, IA   +5 more
core   +1 more source

Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer’s disease

iScience
Summary: Brain waste clearance from the interstitial fluid environment is challenging to measure, which has contributed to controversy regarding the significance of glymphatic transport impairment for neurodegenerative processes.
Sunil Koundal, Xinan Chen, Zachary Gursky, Hedok Lee, Kaiming Xu, Feng Liang, Zhongcong Xie, Feng Xu, Hung-Mo Lin, William E. Van Nostrand, Xianfeng Gu, Rena Elkin, Allen Tannenbaum, Helene Benveniste   +13 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Séminaire GAP: SAVOIRS ET IDEOLOGIES EN POLITIQUE

, 2012
SAVOIRS ET IDEOLOGIES EN POLITIQUE Genèse, circulation, transmission Programme 2012-13 Un Mercredi par Mois, de 14h à 16h — Bâtiment F Université Paris Ouest Nanterre — Plan du Campus 14 novembre 2012 : Jean-Louis Fournel (Paris 8), autour de l’ouvrage ...
gap
core  

Design and Parameter Study of a Self-Compensating Hydrostatic Rotary Bearing

International Journal of Rotating Machinery, 2013
The influence of design parameters on the static performance of a newly designed self-compensating hydrostatic rotary bearing was investigated. The bearing was designed by incorporating the main attributes of angled-surface self-compensating bearing and ...
Xiaobo Zuo, Shengyi Li, Ziqiang Yin, Jianmin Wang   +3 more
doaj   +1 more source

Séminaire "Savoirs et idéologiques en politique" - 18/05/2011 - "Parler et agir au nom des 'non-humains'"

, 2011
Université Paris Ouest Nanterre Séminaire du Groupe d’Analyse Politique Savoirs et idéologies en politique Genèse, circulation, transmission Responsables : Arnault SKORNICKI askornicki@yahoo.fr Laurent BONELLI laurent.bonelli@conflits.org Mercredi 18 mai
gap
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source