Results 111 to 120 of about 1,846,891 (255)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Calendrier 2011-2012 – Séminaire “Savoirs et idéologies en politique”

, 2011
Savoirs et idéologies en politique Genèse, circulation, transmission   Séminaire du Groupe d’Analyse Politique Un Mercredi par Mois, de 14h30 à 16h30 Bâtiment F – Salle des Actes (141)   Calendrier des Séances 2011-2012 16 novembre 2011 : « Comment ...
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer’s disease

Signal Transduction and Targeted Therapy
Alzheimer’s disease (AD) is a major cause of dementia and a prevalent age-related neurodegenerative disorder characterized by progressive cognitive impairment and memory loss.
Seung Jae Hyeon, Seung Chan Kim, Jiyeon Chu, Yeonseo Kim, Chaebin Kim, Uiyeol Park, Zahid Tufail, Phuong Thi Thanh Nguyen, Ahreum Eom, Sojung Kim, Yeyun Kim, Eunkyung Lee, Suhyun Kim, Seung Eun Lee, Jiwan Woo, Jin-A Lee, Kyung Eun Lee, Thor D. Stein, Hyunbeom Lee, Junghee Lee, Hoon Ryu   +20 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Séminaire GAP Savoirs et idéologies en politique: Les Sciences Camérales (4 avril)

, 2012
Université Paris Ouest Nanterre Savoirs et idéologies en politique Genèse, circulation, transmission Séminaire du Groupe d’Analyse Politique Mercredi 4 avril 2012, 14h30 :  Pascale LABORIER (professeur de science politique à Paris Ouest Nanterre, ISP ...
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Effects of Double-Leakage Tip Clearance Flow on the Performance of a Compressor Stage with a Large Rotor Tip Gap [PDF]

, 2016
Effects of a large rotor tip gap on the performance of a one and half stage axial compressor are investigated in detail with a numerical simulation based on LES and available PIV data.
Hah, Chunill
core  

GAP SS&H Newsletter (Vol 2 Issue 1)

, 2013
GAP SS&H Newsletter Volume 2 Issue
GAP SSHRC
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source