Cytokinesis in vertebrate cells initiates by contraction of an equatorial actomyosin network composed of randomly oriented filaments [PDF]
eLife, 2017 The actomyosin ring generates force to ingress the cytokinetic cleavage furrow in animal cells, yet its filament organization and the mechanism of contractility is not well understood.
Felix Spira +8 more
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The Arf GAP Asap promotes Arf1 function at the Golgi for cleavage furrow biosynthesis in Drosophila. [PDF]
Mol Biol Cell, 2016 Drosophila embryo cleavage requires the conserved Arf GAP Asap. Asap seems to recycle Arf1 to the Golgi from post-Golgi membranes for optimal Golgi output and cleavage furrow biosynthesis.
Rodrigues FF, Shao W, Harris TJ.
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A secreted protein promotes cleavage furrow maturation during cytokinesis. [PDF]
Curr Biol, 2011 Developmental modifications in cell shape depend on dynamic interactions between the extracellular matrix and cytoskeleton. In contrast, existing models of cytokinesis describe substantial cell surface remodeling that involves many intracellular regulatory and structural proteins but includes no contribution from the extracellular matrix [1-3].
Xu X, Vogel BE.
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A permeabilized cell model for studying cell division: a comparison of anaphase chromosome movement and cleavage furrow constriction in lysed PtK1 cells. [PDF]
, 1981 After lysis in a Brij 58-polyethylene glycol medium, PtK1 cells are permeable to small molecules, such as erythrosin B, and to proteins, such as rhodamine-labeled FAB, myosin subfragment-1, and tubulin.
W. Zacheus Cande +2 more
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The Trypanosoma brucei AIR9-like protein is cytoskeleton-associated and is required for nucleus positioning and accurate cleavage furrow placement [PDF]
Molecular Microbiology, 2012 AIR9 is a cytoskeleton‐associated protein in Arabidopsis thaliana with roles in cytokinesis and cross wall maturation, and reported homologues in land plants and excavate protists, including trypanosomatids.
S. May +6 more
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Calcium spikes accompany cleavage furrow ingression and cell separation during fission yeast cytokinesis. [PDF]
Mol Biol Cell, 2021 Poddar A, Sidibe O, Ray A, Chen Q.
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Molecular Biology of the Cell, 2013 The BAR domain of amphiphysin is required for endocytic tubule formation at the leading edge of cleavage furrows in Drosophila embryos. In the absence of tubules, furrow ingression is faster, whereas elongated tubules slow furrow ingression, suggesting ...
Jing Su +3 more
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The Ync13-Rga7-Rng10 complex selectively coordinates secretory vesicle trafficking and secondary septum formation during cytokinesis. [PDF]
PLoS BiologyCytokinesis requires precise coordination of contractile-ring constriction, vesicle trafficking and fusion to the plasma membrane, and extracellular matrix assembly/remodeling at the cleavage furrow to ensure faithful cell division and maintain cell ...
Sha Zhang +6 more
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The importance of mechanical constraints for proper polarization and psuedo-cleavage furrow generation in the early Caenorhabditis elegans embryo. [PDF]
PLoS Comput Biol, 2018 Aras BS, Zhou YC, Dawes A, Chou CS.
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Cleavage furrow-directed cortical flows bias mechanochemical pathways for PAR polarization in theC. elegansgerm lineage [PDF]
, 2022 Ng K +4 more
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