bioRxiv, 2020 The role of calcium signaling during cytokinesis has long remained ambiguous. The studies of embryonic cell division discovered that calcium concentration increases transiently at the division plane just before the cleavage furrow ingression, leading to ...
Abhishek Poddar +3 more
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Expanding ring-shaped cleavage furrows in multinucleate cells
Molecular Biology of the Cell, 2023 Mitosis in multinucleate cells of a Dictyostelium mutant may be coupled to central cleavage furrows that arise from areas at which dorsal and basal cell cortices are joined. By membrane fusion, holes are formed that by expanding cleave the cell into portions.
Mary Ecke +2 more
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Actin hitches a ride to the cleavage furrow [PDF]
The Journal of Cell Biology, 2008 ![Graphic][1] Time-lapse images show packages of actin (red, arrows) at the cleavage furrow of a dividing cell. When it comes to efficient packing and shipping, FedEx doesn't have anything on a dividing cell.
Mitch Leslie
openalex +2 more sources
Nature Communications, 2023 Cytokinesis partitions cellular content between daughter cells. It relies on the formation of an acto-myosin contractile ring, whose constriction induces the ingression of the cleavage furrow between the segregated chromatids. Rho1 GTPase and its RhoGEF (
Emilie Montembault +7 more
doaj +1 more source
Role for polo-like kinase 4 in mediation of cytokinesis. [PDF]
, 2019 The mitotic protein polo-like kinase 4 (PLK4) plays a critical role in centrosome duplication for cell division. By using immunofluorescence, we confirm that PLK4 is localized to centrosomes.
Brugge, Joan S +10 more
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A high-resolution shape fitting and simulation demonstrated equatorial cell surface softening during cytokinesis and its promotive role in cytokinesis. [PDF]
PLoS ONE, 2012 Different models for animal cell cytokinesis posit that the stiffness of the equatorial cortex is either increased or decreased relative to the stiffness of the polar cortex.
Hiroshi Koyama +4 more
doaj +1 more source
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. [PDF]
PLoS Biology, 2009 Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small GTPase RhoA, giving rise to a cleavage furrow.
Mark E Burkard +10 more
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Specific accumulation of Rho-associated kinase at the cleavage furrow during cytokinesis: cleavage furrow-specific phosphorylation of intermediate filaments [PDF]
Oncogene, 1999 The small GTPase Rho and one of its targets, Rho-associated kinase (Rho-kinase), are implicated in a wide spectrum of cellular functions, including cytoskeletal rearrangements, transcriptional activation and smooth muscle contraction. Since Rho also plays an essential role in cytokinesis, Rho-kinase may possibly mediate some biological aspects of ...
H, Kosako +9 more
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LET-99 functions in the astral furrowing pathway, where it is required for myosin enrichment in the contractile ring. [PDF]
, 2017 The anaphase spindle determines the position of the cytokinesis furrow, such that the contractile ring assembles in an equatorial zone between the two spindle poles.
Price, Kari L, Rose, Lesilee S
core +1 more source
Polar relaxation by dynein-mediated removal of cortical myosin II [PDF]
, 2020 Nearly 6 decades ago, Lewis Wolpert proposed the relaxation of the polar cell cortex by the radial arrays of astral microtubules as a mechanism for cleavage furrow induction (White and Borisy, 1983; Wolpert, 1960).
Balasubramanian, Mohan K. +4 more
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