Results 61 to 70 of about 89,824 (342)

An Assessment of Pattern of Distribution of Cleft Lip and Palate Patients Reported to A Tertiary Care Hospital in Karachi, A Retrospective Study

Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College, 2021
Objective: To evaluate the  patterns of cleft lip and palate by its type, side, gender, laterality and extent of involvement of hard and/or soft palate in patients reported to a tertiary care hospital in Karachi.
Zubair Ahmed Abbasi, Syeda Arzoo Azeem, Shazia Sarwat Iqbal, Syed Mahmood Shah, Zafar Abbas   +4 more
doaj   +1 more source

Exome Sequencing Reveals the Genetic Architecture of Non‐syndromic Orofacial Clefts and Identifies BOC as a Novel Causal Gene

Advanced Science, EarlyView.
Nonsyndromic orofacial clefts (NSOFCs) are the most common craniofacial defects. Exome sequencing of 214 sporadic cases sheds new light on its genetic architecture and identifies many candidate pathogenic variants. Furthermore, functional studies establish BOC as a novel causal gene and reveal an unusual two‐locus model of inheritance via the epistatic
Qing He, Min Yu, Yuhua Jiao, Yizhu Xu, Xuqin Liang, Wenbin Huang, Linping Xu, Yuxia Hou, Zhanping Ren, Beile Lyu, Zhenwei Qian, Pengpeng Liu, Jing Zhou, Huimei Huang, Chunyan Yin, Huaxiang Zhao, Yi Ding   +16 more
wiley   +1 more source

Prevalence of cleft lip and/or cleft palate in Guangdong province, China, 2015–2018: a spatio-temporal descriptive analysis

BMJ Open, 2021
Objectives This study aimed to investigate the temporal and spatial characteristics of cleft lip and/or palate based on a large-scale birth defect monitoring database.Methods Data on perinatal infants and children with cleft lip and/or palate defects ...
Pi Guo, Yuliang Chen, Bing Li, Degang Wang, Huazhang Miao, Yingxian Zhu, Qinghui Zeng, Xiaolin Yu, Haisheng Wu, Fenghua Liu   +9 more
doaj   +1 more source

Genetics‐Based Targeting Strategies for Precise Neuromodulation

Advanced Science, EarlyView.
In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He, Zhidong Wei, Jianda Xu, Fei Jin, Tong Li, Lili Qian, Juan Ma, Weiying Zheng, Negar Javanmardi, Ting Wang, Kangjian Sun, Zhang‐Qi Feng   +11 more
wiley   +1 more source

Surgical outcome and complications following cleft lip and palate repair in a teaching hospital in Nigeria

African Journal of Paediatric Surgery, 2013
Background: Measurement of treatment outcome is important in estimating the success of cleft management. The aim of this study was to assess the surgical outcome of cleft lip and palate surgery.
Taiwo O Abdurrazaq, Adeyemi O Micheal, Adeyemo W Lanre, Ogunlewe M Olugbenga, Ladeinde L Akin   +4 more
doaj   +1 more source

Evaluation of unilateral cleft lip repairs and the evolution of a new technique based on experience and research [PDF]

, 2011
MSc, Plastic and Reconstructive Surgery, Faculty of Health Sciences, University of the WitwatersrandEvolution of cleft lip repair has been ongoing for many years.
Christofides, Efthimios Andreas
core  

Changes in face-specific neural processes explain reduced cuteness and approachability of infants with cleft lip [PDF]

, 2018
The current study investigated whether changes in the neural processing of faces of infants with a facial abnormality – a cleft lip – mediate effects of the cleft lip on judgments of infant cuteness and approachability. Event-related potentials (ERPs) in
Eilander, J., Huffmeijer, R., Mileva-Seitz, V.R., Rippe, R.C.A.   +3 more
core   +3 more sources

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

Van der Woude syndrome: A review of 11 cases seen at the Lagos University Teaching Hospital

African Journal of Paediatric Surgery, 2014
Background: Van der Woude syndrome (VWS), an autosomal dominant condition associated with clefts of the lip and/or palate and lower lip pits and is caused by mutations in interferon regulatory factor six gene.
Olutayo James, Wasiu L Adeyemo, Christian I Emeka, Mobolanle O Ogunlewe, Akinola L Ladeinde, Azeez Butali   +5 more
doaj   +1 more source

Early academic achievement in children with isolated clefts: a population-based study in England. [PDF]

, 2017
OBJECTIVES: We used national data to study differences in academic achievement between 5-year-old children with an isolated oral cleft and the general population. We also assessed differences by cleft type.
Charman, Susan C, Copley, Lynn P, Deacon, Scott A, Dearden, Lorraine, Fitzsimons, Kate Jane, Setakis, Efrosini, van der Meulen, Jan H   +6 more
core   +1 more source