Results 71 to 80 of about 94,979 (341)

Single‐Nucleus RNA Sequencing Reveals Mid‐Gestational Neurodevelopment Features in the Superior Temporal Plane from Fetuses with Nonsyndromic Cleft Lip and Palate

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong, Xin‐Wei Huang, Qiu‐Xia Xiao, Ying‐Gang Zheng, Hao‐Yue Qin, Chang‐Le Fang, Li Chen, Ruo‐Lan Du, Qiu‐Lin Wang, Li‐Ren Huangfu, Ye‐Qing Fei, Yang‐Yang Zhao, Chen‐Yang Zhai, Ze‐Mian Chen, Shi‐Kun Yuan, Yu‐Ji Zhou, Xing‐Man He, Ting‐Ting Zhi, Xiao‐He Tian, Ting‐Hua Wang   +19 more
wiley   +1 more source

Surgical outcome and complications following cleft lip and palate repair in a teaching hospital in Nigeria

African Journal of Paediatric Surgery, 2013
Background: Measurement of treatment outcome is important in estimating the success of cleft management. The aim of this study was to assess the surgical outcome of cleft lip and palate surgery.
Taiwo O Abdurrazaq, Adeyemi O Micheal, Adeyemo W Lanre, Ogunlewe M Olugbenga, Ladeinde L Akin   +4 more
doaj   +1 more source

Evaluation of unilateral cleft lip repairs and the evolution of a new technique based on experience and research [PDF]

, 2011
MSc, Plastic and Reconstructive Surgery, Faculty of Health Sciences, University of the WitwatersrandEvolution of cleft lip repair has been ongoing for many years.
Christofides, Efthimios Andreas
core  

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Van der Woude syndrome: A review of 11 cases seen at the Lagos University Teaching Hospital

African Journal of Paediatric Surgery, 2014
Background: Van der Woude syndrome (VWS), an autosomal dominant condition associated with clefts of the lip and/or palate and lower lip pits and is caused by mutations in interferon regulatory factor six gene.
Olutayo James, Wasiu L Adeyemo, Christian I Emeka, Mobolanle O Ogunlewe, Akinola L Ladeinde, Azeez Butali   +5 more
doaj   +1 more source

Top‐Down Fabricated Wood‐Derived Pressure and Strain Sensors: A Review

Advanced Science, EarlyView.
This review focuses on wood‐derived pressure/strain sensors fabricated via top‐down strategies. It analyzes wood's structural composition, examines processing techniques, discusses sensor types and sensing mechanisms, and reviews existing research. The article concludes with future directions for enhancing performance and scalability.
Yi Ren, Fuyao Liu, Yanan Zhong, Shengbo Ge, Zhipeng Shi, Siling Lin, Hongli Song, Yingying Zhang, Wei Fan   +8 more
wiley   +1 more source

Pbx loss in cranial neural crest, unlike in epithelium, results in cleft palate only and a broader midface. [PDF]

, 2018
Orofacial clefting represents the most common craniofacial birth defect. Cleft lip with or without cleft palate (CL/P) is genetically distinct from cleft palate only (CPO).
Berkes, Blaschke, Brendolan, Britanova, Buck, Bush, Capellini, Capellini, Capellini, Capellini, Choe, Clement-Jones, Cox, Cuadra-Blanco, Dixon, Dobreva, Elahi, Ferguson, Ferguson, Ferretti, Ficara, Ficara, Fuchs, Golonzhka, Gordon, Gordon, Gosain, Grebbin, Gritli-Linde, Gritli-Linde, Hebert, Hessle, Hill, Hilliard, Ho, Howe, Hurtado, Kim, Kim, Koss, Kousa, Lan, Lane, Leslie, Lewis, Li, Lidral, Longobardi, Losa, Manyama, Marazita, Martik, McCulley, Miletich, Minoux, Moens, Murphy, Okano, Pauws, Percival, Rhee, Richman, Roberts, Rosset, Sagerstrom, Satokata, Schnabel, Selleri, Selleri, Stankunas, Sun, Tam, Villaescusa, Welsh, Young, Yu, Yu, Zeytinoglu, Zhang   +78 more
core   +1 more source

A Dynamic DNA Nano‐Antioxidant Targeting Galectin‐3 Attenuates Liver Fibrosis via Reducing Macrophage Oxidative Stress

Advanced Science, EarlyView.
This study developed a dynamic DNA nano‐antioxidant (DDN) for Galectin‐3 siRNA delivery, specifically targeting hepatic macrophages to suppress ROS‐driven fibrosis. DDN enhanced hepatic accumulation, restored NRF2 signaling, and attenuated oxidative stress, collagen deposition, and fibrotic progression in a CCl4‐induced cirrhosis model, demonstrating ...
Mengjia Peng, Jianguo Xu, Youjian Hong, Fei Fang, Yan Li, Duo Ci, Bowen Wang   +6 more
wiley   +1 more source

Local expression of inflammatory cytokines in the facial tissue of children with a cleft lip and palate [PDF]

, 2012
The cleft lip and/or palate are among the most common congenital anomalies that occur in early development. Cytokines play an important role in the proliferation, growth, differentiation, survival and the functional activity of many cells and the ...
Akota, Ilze, Pilmane, Mara, Smane, Liene
core   +3 more sources

Genetics of cleft lip and cleft palate [PDF]

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 2013
AbstractOrofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with these birth defects and their family members: from subclinical phenotypes to associated syndromic features that is mirrored by the many genes that contribute to
Elizabeth J, Leslie, Mary L, Marazita
openaire   +2 more sources