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Evaluation of Genetics in the Association Between Cardiorespiratory Fitness and Health
Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 5, May 2026.ABSTRACT
We evaluated how much cardiorespiratory fitness (CRF)‐related genetics contribute to the risk of common noncommunicable diseases (NCDs) and mortality, and whether individuals with different levels of CRF and genetic predispositions differ in health characteristics.L. Joensuu, V. Lukander, P. Herranen, N. P. Tynkkynen, U. Kujala, R. Lopéz‐Bueno, A. N. Nordeidet, M. Klevjer, K. Øvretveit, U. Wisløff, A. Bye, U. Ekelund, M. Ollikainen, FinnGen, Aarno Palotie, Mark Daly, Bridget Riley‐Gills, Howard Jacob, Coralie Viollet, Slavé Petrovski, Alix Berton, Santha Ramakrishnan, Ellen Tsai, Zhihao Ding, Emily Holzinger, Robert Plenge, Joseph Maranville, Mark McCarthy, Rion Pendergrass, Jonathan Davitte, Simonne Longerich, Anders Mälarstig, Anna Vlahiotis, Katherine Klinger, Clement Chatelain, Jorg Blankenstein, Karol Estrada, Robert Graham, Dawn Waterworth, Chris O´Donnell, Nicole Renaud, Tomi P. Mäkelä, Jaakko Kaprio, Minna Ruddock, Petri Virolainen, Antti Hakanen, Terhi Kilpi, Markus Perola, Jukka Partanen, Taneli Raivio, Raisa Serpi, Teija Kekonen, Kati Kristiansson, Veli‐Matti Kosma, Jari Laukkanen, Tom Southerington, Outi Tuovila, Jeffrey Waring, Bridget Riley‐Gillis, Fedik Rahimov, Ioanna Tachmazidou, Alix Berton, Santha Ramakrishnan, Ellen Tsai, Zhihao Ding, Marc Jung, Hanati Tuoken, Shameek Biswas, Benjamin Sun, Rion Pendergrass, Jonathan Davitte, Neha Raghavan, Adriana Huertas‐Vazquez, Jae‐Hoon Sul, Anders Mälarstig, Xinli Hu, Åsa Hedman, Katherine Klinger, Robert Graham, Dawn Waterworth, Nicole Renaud, Ma´en Obeidat, Jonathan Chung, Jonas Zierer, Mari Niemi, Samuli Ripatti, Johanna Schleutker, Markus Perola, Mikko Arvas, Olli Carpén, Reetta Hinttala, Johannes Kettunen, Arto Mannermaa, Katriina Aalto‐Setälä, Mika Kähönen, Jari Laukkanen, Johanna Mäkelä, Lila Kallio, Tiina Wahlfors, Jukka Partanen, Eero Punkka, Raisa Serpi, Sanna Siltanen, Veli‐Matti Kosma, Tiina Jokela, Anu Jalanko, Auli Toivola, Denise Öller, Helen Cooper, Mervi Aavikko, Risto Kajanne, Rodos Rodosthenous, Sofia Kuitunen, Tarja Laitinen, Arto Lehisto, Hafiz Sikandar, Juha Karjalainen, Juha Mehtonen, Masahiro Kanai, Mitja Kurki, Mutaamba Maasha, Pietro Della Briotta Parolo, Samuel Jones, Sanni Ruotsalainen, Susanna Lemmelä, Wei Zhou, Aki Havulinna, L. Elisa Lahtela, Mari Kaunisto, Awaisa Ghazal, Elina Kilpeläinen, Jaska Uimonen, Oluwaseun Alexander Dada, Rigbe Weldatsadik, Sanni Ruotsalainen, Tianduanyi Wang, Timo P. Sipilä, Kati Donner, Anu Loukola, Päivi Ingalsuo, Arto Pietilä, Sami Koskelainen, Susanna Lemmelä, Teemu Paajanen, Tero Hiekkalinna, Priit Palta, Dawit A. Yohannes, Harri Siirtola, Javier Gracia‐Tabuenca, Marika Kaakinen, Mary Pat Reeve, Shanmukha Sampath Padmanabhuni, Shuang Luo, Vincent Llorens, Iina Laak, Jaakko Tyrmi, Janne Isojärvi, Tero Sievänen, Timo Pohjonen, Vidal Fey, Johanna Mäkelä, Pauli Wihuri, Tom Southerington, Meri Lähteenmäki, Reetta Kälviäinen, Valtteri Julkunen, Hilkka Soininen, Anne Remes, Mikko Hiltunen, Jukka Peltola, Minna Raivio, Pentti Tienari, Juha Rinne, Roosa Kallionpää, Juulia Partanen, Adam Ziemann, Nizar Smaoui, Anne Lehtonen, Susan Eaton, Shameek Biswas, Natalie Bowers, Edmond Teng, Rion Pendergrass, Fanli Xu, Laura Addis, John Eicher, Qingqin S Li, Karen He, Ekaterina Khramtsova, Neha Raghavan, Martti Färkkilä, Jukka Koskela, Sampsa Pikkarainen, Airi Jussila, Katri Kaukinen, Timo Blomster, Mikko Kiviniemi, Markku Voutilainen, Mark Daly, Jeffrey Waring, Nizar Smaoui, Fedik Rahimov, Anne Lehtonen, Tim Lu, Natalie Bowers, Rion Pendergrass, Linda McCarthy, Amy Hart, Meijian Guan, Jason Miller, Kirsi Kalpala, Melissa Miller, Xinli Hu, Kari Eklund, Antti Palomäki, Pia Isomäki, Laura Pirilä, Oili Kaipiainen‐Seppänen, Johanna Huhtakangas, Nina Mars, Jeffrey Waring, Fedik Rahimov, Apinya Lertratanakul, Nizar Smaoui, Anne Lehtonen, Coralie Viollet, Marla Hochfeld, Natalie Bowers, Rion Pendergrass, Jorge Esparza Gordillo, Dawn Waterworth, Fabiana Farias, Kirsi Kalpala, Nan Bing, Xinli Hu, Tarja Laitinen, Margit Pelkonen, Paula Kauppi, Hannu Kankaanranta, Terttu Harju, Riitta Lahesmaa, Nizar Smaoui, Coralie Viollet, Susan Eaton, Hubert Chen, Rion Pendergrass, Natalie Bowers, Joanna Betts, Kirsi Auro, Rajashree Mishra, Majd Mouded, Debby Ngo, Teemu Niiranen, Felix Vaura, Veikko Salomaa, Kaj Metsärinne, Jenni Aittokallio, Mika Kähönen, Jussi Hernesniemi, Daniel Gordin, Juha Sinisalo, Marja‐Riitta Taskinen, Tiinamaija Tuomi, Timo Hiltunen, Jari Laukkanen, Amanda Elliott, Mary Pat Reeve, Sanni Ruotsalainen, Dirk Paul, Natalie Bowers, Rion Pendergrass, Audrey Chu, Dermot Reilly, Mike Mendelson, Jaakko Parkkinen, Melissa Miller, Tuomo Meretoja, Heikki Joensuu, Olli Carpén, Johanna Mattson, Eveliina Salminen, Annika Auranen, Peeter Karihtala, Päivi Auvinen, Klaus Elenius, Johanna Schleutker, Esa Pitkänen, Nina Mars, Mark Daly, Relja Popovic, Jeffrey Waring, Bridget Riley‐Gillis, Anne Lehtonen, Margarete Fabre, Jennifer Schutzman, Natalie Bowers, Rion Pendergrass, Diptee Kulkarni, Alessandro Porello, Andrey Loboda, Stefan McDonough, Kai Kaarniranta, Joni A Turunen, Terhi Ollila, Hannu Uusitalo, Juha Karjalainen, Esa Pitkänen, Mengzhen Liu, Erich Strauss, Natalie Bowers, Hao Chen, Rion Pendergrass, Kaisa Tasanen, Laura Huilaja, Katariina Hannula‐Jouppi, Teea Salmi, Sirkku Peltonen, Leena Koulu, Nizar Smaoui, Fedik Rahimov, Anne Lehtonen, David Choy, Rion Pendergrass, Dawn Waterworth, Kirsi Kalpala, Ying Wu, Pirkko Pussinen, Aino Salminen, Tuula Salo, David Rice, Pekka Nieminen, Ulla Palotie, Maria Siponen, Liisa Suominen, Päivi Mäntylä, Ulvi Gursoy, Vuokko Anttonen, Kirsi Sipilä, Rion Pendergrass, Hannele Laivuori, Venla Kurra, Laura Kotaniemi‐Talonen, Oskari Heikinheimo, Ilkka Kalliala, Lauri Aaltonen, Varpu Jokimaa, Johannes Kettunen, Marja Vääräsmäki, Outi Uimari, Laure Morin‐Papunen, Maarit Niinimäki, Terhi Piltonen, Katja Kivinen, Elisabeth Widen, Taru Tukiainen, Mary Pat Reeve, Mark Daly, Niko Välimäki, Eija Laakkonen, Jaakko Tyrmi, Heidi Silven, Eeva Sliz, Riikka Arffman, Susanna Savukoski, Triin Laisk, Natalia Pujol, Mengzhen Liu, Bridget Riley‐Gillis, Rion Pendergrass, Janet Kumar, Iiris Hovatta, Erkki Isometsä, Hanna Ollila, Jaana Suvisaari, Antti Mäkitie, Argyro Bizaki‐Vallaskangas, Sanna Toppila‐Salmi, Tytti Willberg, Elmo Saarentaus, Antti Aarnisalo, Eveliina Salminen, Elisa Rahikkala, Johannes Kettunen, Kristiina Aittomäki, Fredrik Åberg, Joel Rämö, Mark Daly, Mary Pat Reeve, Muhammad Adnan Khan, Johanna Mäkelä, Ilkka Immonen, Kai Kaarniranta, Joni A Turunen, Anneke Den Hollander, Bridget Riley‐Gillis, Mengzhen Liu, Nizar Smaoui, Fabio Baschiera, Hans van Leeuwen, Elke Markert, Brian Yaspan, Charli Harlow, Lea Sarow‐Blat, Dermont Reilly, P. Dunnmon, Sara Gale, Fabiana Farias, Jorge Del‐aguila, Catherine O’Riordan, Samuel Lessard, Suzanne Jacobs, Satu Koskela, Anne Kerola, Elisa Lahtela, Helen Cooper, Johanna Paltta, Jukka Koskela, Mark Daly, Mary Pat Reeve, Vincent Llorens, Martti Färkkilä, Johannes Kettunen, Kaisa Tasanen‐Maatta, Laura Huilaja, Minna Ruddock, Aki Havulinna, Antti Palomäki, Laura Kuusalo, Laura Pirilä, Fedik Rahimov, Jan Freudenberg, Nizar Smaoui, Bram Prins, Coralie Viollet, Eleanor Wheeler, Kousik Kundu, Santosh Atanur, Hans van Leeuwen, Himanshu Manchanda, Karl Heilbron, Martin Rao, Nicole Schmidt, Samu Kurki, Ellen Tsai, Ketian Yu, Stephanie Loomis, Benjamin Sun, Cara Carty, Emily Holzinger, Michael Turchin, Neelakshi Jog, Frank Li, Zhihao Ding, Cameron Adams, Mark McCarthy, Michael Rothenberg, Rion Pendergrass, Diana L.Cousminer, Jagtar Nijjar, Jessica Chao, Joanna C.Betts, Jonathan M.Davitte, Linda McGarthy, Michal Magid, Shashank Jariwala, Dawn Waterworth, Amy Hart, Brice Keyes, John Kwon, Jonathan Sherlock, Matt Loza, Elisabeth Vollmann, Jozsef Karman, Julie Fiore, Rajesh Kamath, Enrico Ferrero, Jonas Zierer, Nikos Patsopoulos, Erin Macdonald‐Dunlop, Jessica Chung, Michael McLean, Hamid Mattoo, Aarno Palotie, Elisa Lahtela, Helen Cooper, Jukka Koskela, Mark Daly, Mary Pat Reeve, Raymond Walters, Rodos Rodosthenous, Jouni Lauronen, Adrian Banerji, Matthew Sampson, Michelle McNulty, Daniel Gordin, Patrik Finne, Mika Kähönen, Tapio Hellman, Teemu Niiranen, Dirk Paul, Ioanna Tachmazidou, Hans van Leeuwen, Johanna Mielke, Juho Immonen, Thomas Battram, Tobias Hogrebe, Ketian Yu, Benjamin Sun, Janie Shelton, Yao Hu, Zhihao Ding, Rion Pendergrass, Sergio Dellepiane, Audrey Chu, Chris Floyd, Dan Swerdlow, Erding Hu, Jonathan Davitte, Prerak Desai, Stephen Haddad, Dermot Reilly, P. Dunnmon, Karol Estrada, Rob Graham, Sahar Mozzafari, Nancy Finkel, Sabina Pfister, Shola Richards, Joshua Chiou, Ying Wu, Katherine Klinger, Matti Vuori, Teemu Niiranen, Bridget Riley‐Gillis, Nizar Smaoui, Alix Berton, Hans van Leeuwen, Chen Li, Emily Holzinger, Anubha Mahajan, Mark Mccarthy, Christopher Deboever, Karol Estrada, Robert Graham, Hye In Kim, Sivakumar Pitchumani, Sumedha Jassal, Åsa Hedman, Aarno Palotie, Austin Argentieri, Aoxing Liu, Eero Vuoksimaa, Elisa Lahtela, Joni Lindbohm, Mark Daly, Mary Pat Reeve, Paavo Häppölä, Zhiyu Yang, Eino Solje, Mikko Hiltunen, Valtteri Julkunen, Ville Leinonen, Hanna Kujala, Aki Havulinna, Roosa Kallionpää, Minttu Marttila, Britney Milkovich, Jan Freudenberg, Andrew Lowe, Ioanna Tachmazidou, Thomas Spargo, Kritika Singh, Peng Jiang, Stephanie Loomis, Anubha Mahajan, Rion Pendergrass, Damien Croteau‐Chonka, John Eicher, Prerak Desai, Chris Whelan, Karen He, Qingqin Li, W Galpern, Yanfei Zhang, Andrei Popescu, Delphine Fagegaltier, Mari Niemi, Nikos Patsopoulos, Katherine Klinger, Aarno Palotie, Elisa Lahtela, Jukka Koskela, Mark Daly, Sanni Ruotsalainen, Susanna Lemmelä, Tarja Laitinen, Salla Ranta, Paavo Häppölä, Paula Kauppi, Tiinamaija Tuomi, Raisa Serpi, Riitta Kaarteenaho, Hannu Kankaanranta, Coralie Viollet, Eleanor Wheeler, Oliver Burren, Christoph Ogris, Eric Simon, LI Frank, Julio Cesar Bolivar Lopez, Yao Hu, Zhihao Ding, Elena Sanchez, Emily Holzinger, Joe Maranville, Lilith Moss, Michael Turchin, Zijie Zhao, Diana Chang, Audrey Chu, Billy Fahy, Jessica Chao, Joanna Betts, Jonathan Davitte, Paola Bronson, Prerak Desai, Dermot Reilly, Mona Selej, P Dunnmon, Jorge Del‐aguila, Jozsef Karman, Travis Barr, Katherine Mccauley, Xiaobo Xia, Madhurima Saxena, Pitchumani Sivakumar, Sumedha Jassal, David Habiel, Guanling Huan, Marika Kaakinen, Mary Pat Reeve, Filip Scheperjans, Andrew Blumenfeld, Britney Milkovich, Jan Freudenberg, Tushar Kumar, Hans van Leeuwen, Juho Immonen, Samu Kurki, Coro Paisan‐Ruiz, Anna Podgornaia, Benjamin Sun, Janie Shelton, Peng Jiang, Stephanie Loomis, Tushar Bhangale, John Eicher, Abolfazl Doostparast Torshizi, Aristide Merola, Oliver Freeman, Simonne Longerich, Mari Niemi, Katherine Klinger, E. 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