Results 41 to 50 of about 1,137,377 (243)

Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity?

Archives of Endocrinology and Metabolism, 2020
Objective Climacterium is associated with elevated leptin levels and increased risk of cardiovascular disorders. Conflicting data diverge on whether high leptin levels in climacterium reflect increasing adipose mass or, at least partially, age-related ...
Ana Cyntia B. N. Maniçoba, Clariano P. Oliveira Neto, Johnny. R. Nascimento, Flávia R. F. Nascimento, Haissa O. Brito, Rui Miguel Gil da Costa, Maria do Carmo L. Barbosa, Manuel dos Santos Faria, Maria do Desterro S. B. Nascimento, Luciane M. O. Brito   +9 more
doaj   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Effect of symptoms of climacteric syndrome, depression and insomnia on self-rated work ability in peri- and post-menopausal women in non-manual employment

Annals of Agricultural and Environmental Medicine, 2019
Objective The aim of the study was evaluation of the relationship between severity of symptoms of climacteric syndrome, depressive disorders and sleep problems, and the self-rated work ability of peri-menopausal and post-menopausal women in non-manual ...
Ewa Humeniuk, Iwona Bojar, Mariusz Gujski, Dorota Raczkiewicz   +3 more
doaj   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Effect of therapeutic massage on insomnia and climacteric symptoms in postmenopausal women

, 2012
Introduction Physiological and psychological alterations in the climacteric period frequently influence women's quality of life. Hot flushes, nocturia, mood alterations, respiratory disturbances, insomnia and restless leg syndrome all affect sleep, and ...
Bittencourt, L. R. A. [UNIFESP], Tufik, S. [UNIFESP], Oliveira, D. S. [UNIFESP], Hachul, H. [UNIFESP], Goto, V. [UNIFESP]   +4 more
core   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Alternative methods of treatment of menopausal syndrome [PDF]

РМЖ. Мать и дитя, 2018
Alternative methods of treatment of menopausal syndrome Ilyina I.Yu., Dobrokhotova Yu.E., Ibragimova D.M. Pirogov Russian National Research Medical University, Moscow Climacteric period is the transition fr om the reproductive phase of life to the
Ilina I.Yu., Yu.E. Dobrokhotova, D.M. Ibragimova   +2 more
doaj  

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Hyperostosis frontalis interna: Observed patterns, prevalence, and dementia associations in older adults

The Anatomical Record, EarlyView.
Abstract Hyperostosis frontalis interna (HFI) is a frequently underrecognized condition characterized by overgrowth of the frontal endocranium, most commonly observed in post‐menopausal women. Although its etiology remains unclear, hormonal influences and a possible relationship with neurocognitive changes have been proposed.
Danielle Felsberg, Kira Morgan, Rickey‐Levon Burch, Madelyn Furr, Zachary Tyson, Steven Lesh   +5 more
wiley   +1 more source

Sociocultural conception of climacteric in the West

Cultura de los Cuidados, 2018
Introduction: Including the sociocultural perspective in the care of women is key to attaining good health. The biomedical model has obviated these factors in the study of climacteric, so that a new female pathology, Climatérico Syndrome, has been ...
Rosa María Cárdaba García, Inés Cárdaba García   +1 more
doaj   +1 more source