Results 21 to 30 of about 2,815,143 (258)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Midwestern Regional Climate Center [PDF]

, 2001
Made available in DSpace on 2016-11-14T22:36:27Z (GMT). No. of bitstreams: 2 ISWSIEM2001-01.pdf: 146176 bytes, checksum: 791a8da476fabb8bec8c3d10ae0a0993 (MD5) license.txt: 3973 bytes, checksum: 6c1c5beee39794d995a5ff442f5bd9ab (MD5) Previous issue ...
Midwestern Regional Climate Center
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Seasonal Climate Forecasts and Risk Management Among Georgia Farmers [PDF]

, 2008
Recent increases in the scientific robustness of seasonal climate forecasts have not led to substantial changes in farmers’ risk management strategies of actors, largely because there is poor integration of scientific forecasting into farmers’ decision ...
Hoogenhoom, G., Broad, K., Breuer, N.E, Paz, J., Ingram, K.T, Roncoli, C., Ingram, K.T., Crane, T.A, Breuer, N.E., Crane, T.A., Broad, K, Roncoli, C, Hoogenhoom, G, Paz, J   +13 more
core  

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Sixth Oregon climate assessment

Consistent with its charge under Oregon House Bill 3543, the Oregon Climate Change Research Institute (OCCRI) conducts a biennial assessment of the state of climate change science, including biological, physical, and social science, as it relates to ...
Fleishman, Erica, Oregon Climate Change Research Institute   +1 more
core   +3 more sources

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Declaração de Fortaleza Declaration of Fortaleza

Sustentabilidade em Debate, 2010
Declaração de FortalezaDeclaration of ...
2010 International Conference on Climate, Sustainability and Development in Semi-arid Regions
doaj  

Hysteresis of the Antarctic Ice Sheet With a Coupled Climate‐Ice‐Sheet Model

Geophysical Research Letters
The stability of the Antarctic ice sheet under different fixed CO2 levels and orbital configurations is explored using a coupled climate‐ice sheet model, starting from either a pre‐industrial ice sheet or an ice‐free, isostatically rebounded geometry ...
G. Leloup, A. Quiquet, D. M. Roche, C. Dumas, D. Paillard   +4 more
doaj   +1 more source

Effectiveness of climate change education—a meta-analysis

Frontiers in Education
Climate change is one of the most pressing issues of our times. Consequently, climate change education (CCE) should prepare students to mitigate the effects of climate change and adapt to its consequences through promoting climate literacy.
Vanessa Marie-Jane Aeschbach, Martin Schwichow, Martin Schwichow, Werner Rieß   +3 more
doaj   +1 more source