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Understanding New Zealand public opinion on climate change : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Politics at Massey University, Manawatū, New Zealand [PDF]

, 2017
This project explored how climate change is understood by members of the New Zealand public and how these understandings relate to their climate-related policy preferences and actions.
Allan, Ross
core  

Labor Leading on Climate: A Policy Platform to Address Rising Inequality and Rising Sea Levels in New York State [PDF]

, 2017
With the renewed need for state action, this paper presents a case study of a labor-led initiative in New York State that seeks to address both economic inequality and the climate crisis.
Cha, J. Mijin
core   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Mainstreaming systematic climate action in energy infrastructure to support the sustainable development goals

npj Climate Action
The energy sector is the largest emitter of greenhouse gas emissions, accounting for 37% of the world’s combined emissions, and plays a key role in achieving the Sustainable Development Goals.
Louise Wernersson, Simon Román, Francesco Fuso Nerini, Robert Mutyaba, Samantha Stratton-Short, Daniel Adshead   +5 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Burning Forest Biomass Is Not an Effective Climate Mitigation Response and Conflicts With Biodiversity Adaptation

Climate Resilience and Sustainability
Pathways are proposed for progressing the goal of decarbonizing economies that rely on burning forest biomass for heat and electricity (bioenergy) based on the proposition that this creates benefits for the climate.
B. G. Mackey, D. B. Lindenmayer, H. Keith, J. de Bie   +3 more
doaj   +1 more source

Seed-Derived Synthetic Microbial Communities (SynComs) from Medicago Wild Relatives Modulate Early Plant Microbiome Assembly and Phenotypic Traits in Lucerne (Medicago sativa L.)

Microorganisms
Seed-associated microbiomes represent an underexplored frontier in synthetic community (SynCom) design, particularly in forage legumes such as lucerne (Medicago sativa L.), where early microbial assembly can shape plant development.
Shenali Subodha Herath Dissanayakalage, Jatinder Kaur, Tongda Li, Adam M. Dimech, Timothy I. Sawbridge   +4 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Effects of Concentrate Feed Starch Source Offered Twice a Day on Feed Intake and Milk Production of Cows During the Early Postpartum Period

Animals
This experiment determined the effects of two different starch sources when offered twice a day to cows during the early postpartum period (1 to 23 d postpartum, treatment period) on dry matter intake (DMI), feeding behavior, and milk production.
Rodrigo I. Albornoz, Victoria M. Russo, Christie K. M. Ho, Khageswor Giri, Michael S. Allen, Adam L. Lock, William J. Wales, Matthew I. Knight   +7 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source