Results 41 to 50 of about 1,390,750 (253)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Burning Forest Biomass Is Not an Effective Climate Mitigation Response and Conflicts With Biodiversity Adaptation

open access: yesClimate Resilience and Sustainability
Pathways are proposed for progressing the goal of decarbonizing economies that rely on burning forest biomass for heat and electricity (bioenergy) based on the proposition that this creates benefits for the climate.
B. G. Mackey   +3 more
doaj   +1 more source

Seed-Derived Synthetic Microbial Communities (SynComs) from Medicago Wild Relatives Modulate Early Plant Microbiome Assembly and Phenotypic Traits in Lucerne (Medicago sativa L.)

open access: yesMicroorganisms
Seed-associated microbiomes represent an underexplored frontier in synthetic community (SynCom) design, particularly in forage legumes such as lucerne (Medicago sativa L.), where early microbial assembly can shape plant development.
Shenali Subodha Herath Dissanayakalage   +4 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham   +7 more
wiley   +1 more source

Effects of Concentrate Feed Starch Source Offered Twice a Day on Feed Intake and Milk Production of Cows During the Early Postpartum Period

open access: yesAnimals
This experiment determined the effects of two different starch sources when offered twice a day to cows during the early postpartum period (1 to 23 d postpartum, treatment period) on dry matter intake (DMI), feeding behavior, and milk production.
Rodrigo I. Albornoz   +7 more
doaj   +1 more source

Cities and climate change: Strategic options for philanthropic support [PDF]

open access: yes, 2019
Now, more than ever, cities are at the front lines of U.S. climate action. As national action stalls, there is still a daunting amount to be done in reducing human-generated climate emissions. Fortunately, this report comes in the wake of a groundswell
Cleveland, John   +3 more
core  

Labor Leading on Climate: A Policy Platform to Address Rising Inequality and Rising Sea Levels in New York State [PDF]

open access: yes, 2017
With the renewed need for state action, this paper presents a case study of a labor-led initiative in New York State that seeks to address both economic inequality and the climate crisis.
Cha, J. Mijin
core   +2 more sources

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim   +3 more
wiley   +1 more source

Science and ethics in the post-political era: strategies within the Camp for Climate Action [PDF]

open access: yes, 2012
Despite a peak in activism against climate change in the UK, new environmental direct action networks have not yet received much academic attention. This article takes as a case study perhaps the most prominent of such networks – the Camp for Climate ...
Bowman, Andrew   +2 more
core   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron   +5 more
wiley   +1 more source

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