Results 191 to 200 of about 130,883 (268)

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Climate adaptation in Populus trichocarpa: key adaptive loci identified for stomata and leaf traits. [PDF]

New Phytol
Klein MC, Meng Z, Bailey-Bale J, Milner S, Shi P, Muchero W, Chen JG, Tschaplinski TJ, Jacobson D, Lagergren J, Lane M, O'Brien C, Chhetri H, Abeyratne CR, Shu M, Freer-Smith P, Buckley TN, Magney TS, Monroe JG, Tuskan GA, Taylor G.   +20 more
europepmc   +1 more source

SiDT1 Defines Plant Architecture Reminiscent of Green Revolution in Foxtail Millet

Advanced Science, EarlyView.
SiDT1 encodes a GA3‐oxidase that creates a semi‐dwarf, lodging‐resistant architecture reminiscent of the rice Green Revolution. The resulting ideotype performs well under dense planting and provides a valuable genetic resource for high‐yield, mechanized foxtail millet production. ABSTRACT Foxtail millet (Setaria italica) is a drought‐tolerant C4 cereal
Jianzhen Lv, Jinjin Cheng, Zhen Hu, Qian Lan, Yanjun Yang, Chengcheng Pei, Junhao Luo, Zhuang Li, Peiyong Xin, Jijun Yan, Jinfang Chu, Qian Qian, Zhaosheng Kong, Liang Jiang   +13 more
wiley   +1 more source

Haploblocks contribute to parallel climate adaptation following global invasion of a cosmopolitan plant. [PDF]

Nat Ecol Evol
Battlay P, Hendrickson BT, Mendez-Reneau JI, Santangelo JS, Albano LJ, Wilson J, Caizergues AE, King N, Puentes A, Tudoran A, Violle C, Vasseur F, Patterson CM, Foster M, Stamps C, Innes SG, Allio R, Angeoletto F, Anstett DN, Anstett J, Bucharova A, Comerford MS, David S, Falahati-Anbaran M, Godsoe W, González-Lagos C, Gundel PE, Hood GR, Lampei C, Lara C, Lázaro-Lobo A, Silva Leandro D, Merritt TJS, Mitchell N, Mohammadi Bazargani M, Moles A, Murúa M, Paule J, Pfeiffer V, Raeymaekers JAM, Rennison DJ, Rios RS, Rowntree JK, Schneider AC, Stack Whitney K, Tamburrino Í, VanWallendael A, Kim PY, Ness RW, Johnson MTJ, Hodgins KA, Kooyers NJ.   +51 more
europepmc   +1 more source

Multiscale Coupling From Mastication to Retronasal Aroma Perception: The PG‐DTCFN Model and Multiphysics Simulation

Advanced Science, EarlyView.
Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen, Xiongfeng He, Zihao Li, Zidong Chen, Jiajin Sun, Xinyu Jiang, Yunhui Zhang, Lizhang Wu, Ran Wang, Jingnan Lu, Bo Wang, Kezhou Cai, Baocai Xu   +12 more
wiley   +1 more source

Whole Genome Resequencing Reveals the Genetic Basis of Desert Arid Climate Adaptation in Lop Sheep. [PDF]

Animals (Basel)
Yang C, Gong C, Khamili A, Li X, Gao Q, Chen H, Xiang X, Wang J, Han C, Gao Q.   +9 more
europepmc   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Narratives of climate adaptation and linkages to psychosocial and nutritional health in a Zimbabwean rural community. [PDF]

World Dev Sustain
Bhatasara S, Nwosu C, Macheka L, Nyamwanza AM.   +3 more
europepmc   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Thermal Vulnerability and Potential Cultivation Areas of Four Day-Neutral Strawberries in Chile: Implications for Climate Adaptation. [PDF]

Plants (Basel)
Sierra-Almeida A, Morales LV, Guerrero D, Hasbún RJN, Retamal L, Garrido-Bigotes A, Tamburrino Í, Maruri A.   +7 more
europepmc   +1 more source