Results 191 to 200 of about 129,940 (268)

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Haploblocks contribute to parallel climate adaptation following global invasion of a cosmopolitan plant. [PDF]

Nat Ecol Evol
Battlay P, Hendrickson BT, Mendez-Reneau JI, Santangelo JS, Albano LJ, Wilson J, Caizergues AE, King N, Puentes A, Tudoran A, Violle C, Vasseur F, Patterson CM, Foster M, Stamps C, Innes SG, Allio R, Angeoletto F, Anstett DN, Anstett J, Bucharova A, Comerford MS, David S, Falahati-Anbaran M, Godsoe W, González-Lagos C, Gundel PE, Hood GR, Lampei C, Lara C, Lázaro-Lobo A, Silva Leandro D, Merritt TJS, Mitchell N, Mohammadi Bazargani M, Moles A, Murúa M, Paule J, Pfeiffer V, Raeymaekers JAM, Rennison DJ, Rios RS, Rowntree JK, Schneider AC, Stack Whitney K, Tamburrino Í, VanWallendael A, Kim PY, Ness RW, Johnson MTJ, Hodgins KA, Kooyers NJ.   +51 more
europepmc   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Whole Genome Resequencing Reveals the Genetic Basis of Desert Arid Climate Adaptation in Lop Sheep. [PDF]

Animals (Basel)
Yang C, Gong C, Khamili A, Li X, Gao Q, Chen H, Xiang X, Wang J, Han C, Gao Q.   +9 more
europepmc   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Narratives of climate adaptation and linkages to psychosocial and nutritional health in a Zimbabwean rural community. [PDF]

World Dev Sustain
Bhatasara S, Nwosu C, Macheka L, Nyamwanza AM.   +3 more
europepmc   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Thermal Vulnerability and Potential Cultivation Areas of Four Day-Neutral Strawberries in Chile: Implications for Climate Adaptation. [PDF]

Plants (Basel)
Sierra-Almeida A, Morales LV, Guerrero D, Hasbún RJN, Retamal L, Garrido-Bigotes A, Tamburrino Í, Maruri A.   +7 more
europepmc   +1 more source

Causal‐Guided Ultra‐Long‐Term Time Series Forecasting Via Anticipated Covariates

Advanced Science, EarlyView.
Often treated as unknown, information from the future remains underutilized.We demonstrate that in a coupled dynamical system, providing the future state of the effect enables accurate forecasting of the cause for a long timesteps. A time series forecasting paradigm that introduces anticipated covariates to represent such known future states is ...
Jintong Zhao, Yufei Liu, Ruixi Huang, Zhongxue Gan, Siyang Leng   +4 more
wiley   +1 more source

International climate adaptation assistance: Assessing public support in Switzerland. [PDF]

PLoS One
Andonova L, Zucca A, Montfort S, Dolšak N, Prakash A.   +4 more
europepmc   +1 more source