Results 31 to 40 of about 7,128,396 (294)

Hybrid bottom-up and top-down framework resolves discrepancies in Canada’s oil and gas methane inventories

Communications Earth & Environment
Estimating accurate oil and gas methane emissions has been a global challenge, highlighted by a twofold discrepancy between atmospheric measurement-based estimates and emission inventories.
Elton Chan, Felix Vogel, Steve Smyth, Owen Barrigar, Misa Ishizawa, Jinwoong Kim, Michael Neish, Douglas Chan, Douglas E. J. Worthy   +8 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Fifth Oregon climate assessment

Consistent with its charge under Oregon House Bill 3543, the Oregon Climate Change Research Institute (OCCRI) conducts a biennial assessment of the state of climate change science, including biological, physical, and social science, as it relates to ...
Fleishman, Erica, Oregon Climate Change Research Institute, Dalton, Meghan M.   +2 more
core   +6 more sources

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Growth Performance and Biomass of Selected Indigenous Tree Species in the Permanent Nursery, Addis Zemen, Northwest Ethiopia

International Journal of Forestry Research
The production of seedlings from selected indigenous tree species is influenced by the type of potting media and soil ratios. A nursery experiment was conducted in the Libo Kemekem District of Addis Zemen, northwest Ethiopia, to assess the growth ...
Tewachew Worku, Melkamu Abere, Solomon Guday, Sintayehu Getie, Zelalem Teshager, Aklilu Agidie, Abeje Eshete   +6 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Climate change 2015: growing risks, critical choices [PDF]

, 2015
This latest Climate Council report provides an update of climate change science, impacts and risks. This report draws from the massive body of evidence that human activities - primarily from the burning of coal, oil and gas - are driving dramatic changes
Climate Council
core  

Human driven climate change increased the likelihood of the 2023 record area burned in Canada

npj Climate and Atmospheric Science
In 2023, wildfires burned 15 million hectares in Canada, more than doubling the previous record. These wildfires caused a record number of evacuations, unprecedented air quality impacts across Canada and the northeastern United States, and substantial ...
Megan C. Kirchmeier-Young, Elizaveta Malinina, Quinn E. Barber, Karen Garcia Perdomo, Salvatore R. Curasi, Yongxiao Liang, Piyush Jain, Nathan P. Gillett, Marc-André Parisien, Alex J. Cannon, Aranildo R. Lima, Vivek K. Arora, Yan Boulanger, Joe R. Melton, Laura Van Vliet, Xuebin Zhang   +15 more
doaj   +1 more source

Characterizing the Great Lakes Coastal Wetlands with InSAR Observations from X-, C-, and L-Band Sensors

Canadian Journal of Remote Sensing, 2020
We investigated the potential of using Synthetic Aperture Radar (SAR) imagery from three different frequencies: X-, C-, and L-band, to characterize coastal wetlands in the Great Lakes.
Zhaohua Chen, Sarah Banks, Amir Behnamian, Lori White, Benoit Montpetit, Jon Pasher, Jason Duffe   +6 more
doaj   +1 more source