Results 31 to 40 of about 3,277,034 (311)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Measured Canadian oil sands CO2 emissions are higher than estimates made using internationally recommended methods

Nature Communications, 2019
Evaluating GHG emissions reported to inventories for the oil and gas (O&G) sector is important for countries with resource-based economies. Here the authors provide a top-down assessment of GHG emissions from the Canadian oil sands and find previous ...
John Liggio, Shao-Meng Li, Ralf M. Staebler, Katherine Hayden, Andrea Darlington, Richard L. Mittermeier, Jason O’Brien, Robert McLaren, Mengistu Wolde, Doug Worthy, Felix Vogel   +10 more
doaj   +1 more source

Indirect interactions between pollinators drive interaction rewiring through space

Ecosphere, 2023
In recent years, an extended body of literature has focused on the importance of either temporal or spatial dynamics in shaping the structure of interacting plant and pollinator communities.
Ainhoa Magrach, Maddi Artamendi, Paula Dominguez Lapido, Clara Parejo, Encarnacion Rubio   +4 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Growth Performance and Biomass of Selected Indigenous Tree Species in the Permanent Nursery, Addis Zemen, Northwest Ethiopia

International Journal of Forestry Research
The production of seedlings from selected indigenous tree species is influenced by the type of potting media and soil ratios. A nursery experiment was conducted in the Libo Kemekem District of Addis Zemen, northwest Ethiopia, to assess the growth ...
Tewachew Worku, Melkamu Abere, Solomon Guday, Sintayehu Getie, Zelalem Teshager, Aklilu Agidie, Abeje Eshete   +6 more
doaj   +1 more source

Big geospatial data analysis for Canada’s Air Pollutant Emissions Inventory (APEI): using google earth engine to estimate particulate matter from exposed mine disturbance areas

GIScience & Remote Sensing, 2020
Particulate Matter (PM) emissions originating from mine waste and mine tailings can be hazardous to human health, depending on the ore type and processes used to extract ore.
Meyra Fuentes, Koreen Millard, Emil Laurin   +2 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Human driven climate change increased the likelihood of the 2023 record area burned in Canada

npj Climate and Atmospheric Science
In 2023, wildfires burned 15 million hectares in Canada, more than doubling the previous record. These wildfires caused a record number of evacuations, unprecedented air quality impacts across Canada and the northeastern United States, and substantial ...
Megan C. Kirchmeier-Young, Elizaveta Malinina, Quinn E. Barber, Karen Garcia Perdomo, Salvatore R. Curasi, Yongxiao Liang, Piyush Jain, Nathan P. Gillett, Marc-André Parisien, Alex J. Cannon, Aranildo R. Lima, Vivek K. Arora, Yan Boulanger, Joe R. Melton, Laura Van Vliet, Xuebin Zhang   +15 more
doaj   +1 more source

Observations from C-Band SAR Fully Polarimetric Parameters of Mobile Sea Ice Based on Radar Scattering Mechanisms to Support Operational Sea Ice Monitoring

Canadian Journal of Remote Sensing, 2022
Fully polarimetric (FP) SAR systems offer parameters that describe and quantify the scattering mechanisms from the surface cover. These are usually derived from decomposition of matrices derived from the original scattering matrix from observations at ...
Mohammed Shokr, Mohammed Dabboor, Melanie Lacelle, Tom Zagon, Benjamin Deschamps   +4 more
doaj   +1 more source

Climate Change and Climate Science [PDF]

Science, 2004
T here is a paradoxical gulf between the importance of Earth's climate and the level of public interest in it. To be sure, tornadoes, killer heat waves, and floods make the headlines, but it's important to remember that weather is not climate. Some of the public's confusion may relate to a certain failure to make that distinction, as in the occasional ...
openaire   +2 more sources