Results 101 to 110 of about 7,601,175 (265)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Economic burden of ambulance transports for patients with heatstroke under climate change: comparison of the effects of gradual temperature increases and extreme heat events

Environmental Research Communications
Although the risk of heatstroke is already severe in Japan, it is expected to increase due to climate change. Researchers have mainly focused on future increases in heatstroke morbidity and mortality to project the risk of heatstroke in Japan.
Kazutaka Oka, Jinyu He, Yasushi Honda, Yasuaki Hijioka   +3 more
doaj   +1 more source

Climate adaptation manual for local government: embedding resilience to climate change [PDF]

, 2014
This manual highlights leading case studies and practical resources from Australian municipalities and overseas, and includes a step-by-step framework for effectively embedding climate risk into council operations.
Jane Inglis, Andrew Dimitriadis, Stefanie Pillora, Stella Whittaker   +3 more
core  

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

A literature review of climate change-related risk factors for cancer development

Environmental Research: Health
The effects of climate change are wide-reaching, impacting both natural ecosystems and human populations, with the increased exposure to ultraviolet (UV) radiation and high temperatures causing extensive health problems and disruptions in food and water ...
Vanessa Engelke da Silva, Xiuquan Wang, William Montelpare, Pelin Kinay   +3 more
doaj   +1 more source

Supporting evidence-based adaptation decision-making in the Australian Capital Territory: a synthesis of climate change adaptation research [PDF]

, 2013
This research synthesis provides policy-makers and practitioners with an understanding of the building blocks for effective adaptation decision-making, as evidenced through the NCCARF research program.
Jennifer Cane
core  

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

The capacities of private developers in urban climate change adaptation [PDF]

, 2013
The urban environment is particularly exposed to climate impacts, due to a range of factors, such as its geographical location, spatial immobility, and high population.
Taygfeld, Pazit, Coiacetto, Eddo, Shearer, Heather, Dodson, Jago, Banhalmi-Zakar, Zsuzsa   +4 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Assessing the social risks of flooding for coastal societies: a case study for Prince Edward Island, Canada

Environmental Research Communications
With the worldwide growing threat of flooding, assessing flood risks for human societies and the associated social vulnerability has become a necessary but challenging task.
Tianze Pang, Mohammad Aminur Rahman Shah, Quan Van Dau, Xiuquan Wang   +3 more
doaj   +1 more source