Results 191 to 200 of about 114,786 (267)

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Sustained benefits of long-term biochar application for food security and climate change mitigation. [PDF]

Proc Natl Acad Sci U S A
Yang J, Xia L, van Groenigen KJ, Zhao X, Ti C, Wang W, Du Z, Fan M, Zhuang M, Smith P, Lal R, Butterbach-Bahl K, Han X, Meng J, Liu J, Cai H, Cheng Y, Liu X, Shu X, Jiao X, Pan Z, Tang G, Yan X.   +22 more
europepmc   +1 more source

From Defense Executor to Engineering Target: Harnessing Lignin for Crop Resistance

Advanced Science, EarlyView.
Lignin serves as both a physical and chemical executor of broad‐spectrum plant immunity. This review systematically summarizes classical and recent advances in lignin‐mediated immunity, outlines the multifaceted regulatory modules controlling lignification under biotic stress, discusses key physiological and biochemical mechanisms behind lignin‐based ...
Yanwen Yu, Ke Wang, Huachuan Tuo, Jiankun Li, Liping Xu, Chang‐Jun Liu, Mingyue Gou   +6 more
wiley   +1 more source

Adapting agriculture to climate change

We evaluate the potential impacts and measure the potential limits of adaptation of agriculture to climate change. Pressures on land and water resources are expected to intensify existing risks in low latitude areas – e.g., South-East Asia deltas – and ...
Quiroga, Sonia, Garrote, Luis, Diz, Agustin, Iglesias, Ana   +3 more
core  

Specialist physicians' and management personnel's views on climate change mitigation and adaptation in German healthcare facilities: A nationwide survey on attitudes, implementation, and barriers. [PDF]

J Clim Chang Health
Sasse SC, Schneider F, Conway N, Doblinger C, Kolpatzik K, Schulz CM, Baumann AAW, Mezger NCS.   +7 more
europepmc   +1 more source

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

Addressing critiques refines global estimates of reforestation potential for climate change mitigation. [PDF]

Nat Commun
Fesenmyer KA, Poor EE, Terasaki Hart DE, Veldman JW, Fleischman F, Choksi P, Archibald S, Armani M, Fagan ME, Fricke EC, Terrer C, Hasler N, Williams CA, Ellis PW, Cook-Patton SC.   +14 more
europepmc   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

Oyster farming acts as a marine carbon dioxide removal (mCDR) hotspot for climate change mitigation. [PDF]

Proc Natl Acad Sci U S A
Chen XW, Zhang Z, Pan MJ, Liu Y, Li CL, Zhou YG, Li L, Dong X, Dong YW, Li JY, Liu SM, Wang XN, Tian SJ, Liu Y, Zhang JH, Qiu YG, Wang XG, Cai WJ, Tian XL, Kao SJ, Dong SL.   +20 more
europepmc   +1 more source

A Modular PLUG‐IN Photosynthetic Chassis With Tunable Thermal Control for Mammalian Systems

Advanced Science, EarlyView.
This work establishes a “plug‐in” chassis compatible with mammalian systems that synchronizes growth, production, and cell‐wall re‐configuration, providing a versatile platform for photosynthetic bioproduction and microalgal synthetic biology. ABSTRACT Microalgae are promising photosynthetic platforms for high‐value compounds, yet their industrial use ...
Qinhua Gan, Zheng Li, Yunfei Chen, Mingting Du, Qianyi Wu, Congcong Miao, Tao Xu, Shan Wu, Xitao Chen, Xingwei Huang, Yuhui Cheng, Chengcheng Li, Yi Xin, Yandu Lu   +13 more
wiley   +1 more source