Results 51 to 60 of about 824,470 (298)

Reactive halogens increase the global methane lifetime and radiative forcing in the 21st century

Nature Communications, 2022
Methane is a powerful greenhouse gas and previous studies focus on its sources with less attention on the loss. Here the authors show that reactive halogen species, not considered in climate projections, significantly reduces the methane loss, increasing
Qinyi Li, Rafael P. Fernandez, Ryan Hossaini, Fernando Iglesias-Suarez, Carlos A. Cuevas, Eric C. Apel, Douglas E. Kinnison, Jean-François Lamarque, Alfonso Saiz-Lopez   +8 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Climate persistence and memory

Tellus: Series A, Dynamic Meteorology and Oceanography, 2020
The autocorrelation function (ACF) and its relationship to fluctuation analysis (FA) are discussed, based on the reanalysis monthly mean geopotential height at 500 hPa from ECMWF (ERA-20C).
Jiangnan Li, Zhian Sun
doaj   +1 more source

Radiative absorption enhancements by black carbon controlled by particle-to-particle heterogeneity in composition. [PDF]

, 2020
Black carbon (BC) absorbs solar radiation, leading to a strong but uncertain warming effect on climate. A key challenge in modeling and quantifying BC's radiative effect on climate is predicting enhancements in light absorption that result from internal ...
Bhandari, Janarjan, Cappa, Christopher D, China, Swarup, Davidovits, Paul, Fierce, Laura, Fischer, D Al, Helgestad, Taylor, Lambe, Andrew T, Mazzoleni, Claudio, Onasch, Timothy B, Sedlacek, Arthur J, Smith, Geoffrey D, Wolff, Lindsay   +12 more
core  

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

The impact of the mesh size and microphysics scheme on the representation of mid-level clouds in the ICON model in hilly and complex terrain [PDF]

Atmospheric Chemistry and Physics
The rise in computational power in recent years has enabled research and national weather services to conduct high-resolution simulations down to the kilometric (Δx=𝒪(1 km)) and even to hectometric (Δx=𝒪(100 m)) scales for both weather and climate ...
N. Omanovic, B. Goger, U. Lohmann
doaj   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim, Han Gil Seo, Roh‐Eul Yoo, Byung‐Mo Oh   +3 more
wiley   +1 more source

Enhanced Global Monsoon in Present Warm Period Due to Natural and Anthropogenic Forcings

Atmosphere, 2018
In this study, we investigate global monsoon precipitation (GMP) changes between the Present Warm Period (PWP, 1900–2000) and the Little Ice Age (LIA, 1250–1850) by performing millennium sensitivity simulations using the Community Earth System Model ...
Jing Chai, Fei Liu, Jian Liu, Xinyong Shen   +3 more
doaj   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source