Results 71 to 80 of about 1,748,129 (280)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Effects of Pacific Intertropical Convergence Zone precipitation bias on ENSO phase transition

Environmental Research Letters, 2014
In this study, the effect of mean precipitation bias over the Pacific Intertropical Convergence Zone (ITCZ) on the El Niño southern oscillation (ENSO) transition is examined using CMIP3 and CMIP5 archives.
Yoo-Geun Ham, Jong-Seong Kug
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Energy Constraints for Climate Models from Hydrologic Partitioning

, 2019
It is well known that evaporative cooling of Earth's surface water reduces the amount of radiation that goes into sensible heat, namely the portion of radiation that produces higher temperatures.
Calabrese, Salvatore, Daly, Edoardo, Porporato, Amilcare, Yin, Jun   +3 more
core   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Model performance and surface impacts of atmospheric river events in Antarctica

Discover Atmosphere
There is increasing evidence that atmospheric rivers (ARs) drive extreme precipitation and melt events across Antarctica and that these impacts are more accurately captured in high-resolution models.
Marlen Kolbe, Jose Abraham Torres Alavez, Ruth Mottram, Richard Bintanja, Eveline C. van der Linden, Martin Stendel   +5 more
doaj   +1 more source

The Atmospheric Chemistry and Climate Model Intercomparison Project (ACCMIP): Overview and description of models, simulations and climate diagnostics [PDF]

, 2013
The Atmospheric Chemistry and Climate Model Intercomparison Project (ACCMIP) consists of a series of time slice experiments targeting the long-term changes in atmospheric composition between 1850 and 2100, with the goal of documenting composition changes
Bergmann, D., Cameron-Smith, Philip, Cionni, I, Collins, William J., Dalsoren, Stig B, Doherty, R. M., Eyring, V., Faluvegi, G., Folberth, G., Ghan, S, Horowitz, L. W., Josse, B, Lamarque, J. F., Lee, Y, MacKenzie, Ian A., Nagashima, T, Naik, Vaishali, Plummer, David A, Righi, M, Rumbold, S, Schulz, Michael, Shindell, Drew T., Skeie, R, Stevenson, D. S., Strode, Sarah, Sudo, K., Szopa, Sophie, Voulgarakis, A., Young, Paul, Zeng, Guang   +29 more
core   +4 more sources

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Reversibility of Arctic Sea Ice Retreat - A Multi-Scale Modeling Approach [PDF]

, 2012
Arctic summer sea ice has been retreating rapidly over past decade. Climate model projections show further retreat under typical forcing scenarios. The mode of the retreat is a matter of debate.
Mueller-Stoffels, M.
core  

A spatial analysis of multivariate output from regional climate models [PDF]

, 2011
Climate models have become an important tool in the study of climate and climate change, and ensemble experiments consisting of multiple climate-model runs are used in studying and quantifying the uncertainty in climate-model output.
Cressie, Noel, Furrer, Reinhard, Sain, Stephan R.   +2 more
core   +3 more sources