Results 41 to 50 of about 4,806,651 (288)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Ice Monitoring in Swiss Lakes from Optical Satellites and Webcams Using Machine Learning

open access: yesRemote Sensing, 2020
Continuous observation of climate indicators, such as trends in lake freezing, is important to understand the dynamics of the local and global climate system.
Manu Tom   +5 more
doaj   +1 more source

Bihourly Subterranean Temperature and Relative Humidity Data from the Nullarbor Plain, Australia (Nov 2019–Mar 2021)

open access: yesData, 2022
This research provides bihourly temperature and relative humidity data from ten measuring locations in eight caves from one of the largest contiguous arid karst areas in the world, the Nullarbor Plain in south Australia.
Matej Lipar, Mateja Ferk
doaj   +1 more source

Climate change 2015: growing risks, critical choices [PDF]

open access: yes, 2015
This latest Climate Council report provides an update of climate change science, impacts and risks. This report draws from the massive body of evidence that human activities - primarily from the burning of coal, oil and gas - are driving dramatic changes
Climate Council
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Short-lived Climate Pollutants [PDF]

open access: yes, 2016
Report summarizing the policy-relevant findings of the Arctic Monitoring and Assessment Programme' 2015 assessments of short-lived climate pollutants (Methane, Black carbon, and Ozone)
Arctic Monitoring and Assessment Programme
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

Thirsty country: climate change and drought in Australia [PDF]

open access: yes, 2015
This report argues that climate change is likely making drought worse in the southeast and southwest of Australia, which are some of our most populous regions. Introduction Drought has deeply affected Australia throughout its history.
Climate Council
core  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

INFORMATION TECHNOLOGY OF CLIMATE MONITORING

open access: yesRadio Electronics, Computer Science, Control, 2021
Context. Information monitoring technology is used to reduce information uncertainty about the regularity of air temperature changes during managing work in hard-to-reach places [1]. The task was to create a method for modelling one of the climatic indicators, air temperature, in the given territories in the information monitoring technology structure.
M. V. Talakh, S. V. Holub, I. B. Turkin
openaire   +4 more sources

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