Results 21 to 30 of about 144,720 (218)

Underestimated marine stratocumulus cloud feedback associated with overly active deep convection in models

Environmental Research Letters, 2021
Cloud feedback remains the largest source of uncertainty in equilibrium climate sensitivity (ECS). Many studies have attempted to narrow uncertainties in cloud feedback and ECS by proposing observable metrics with high skill at predicting future climate,
N Hirota, T Ogura, H Shiogama, P Caldwell, M Watanabe, Y Kamae, K Suzuki   +6 more
doaj   +1 more source

Fast‐Forward to Perturbed Equilibrium Climate

Geophysical Research Letters, 2019
The equilibrium climate sensitivity, that is, the global‐mean surface‐air temperature change in response to a doubling of the carbon dioxide concentration is a widely used metric in climate change studies.
D. Saint‐Martin, O. Geoffroy, L. Watson, H. Douville, G. Bellon, A. Voldoire, J. Cattiaux, B. Decharme, A. Ribes   +8 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Observational Evidence for Two Modes of Coupling Between Sea Surface Temperatures, Tropospheric Temperature Profile, and Shortwave Cloud Radiative Effect in the Tropics

Geophysical Research Letters, 2019
Tropical average shortwave cloud radiative effect (SWCRE) anomalies observed by CERES/EBAF v4 are explained by observed average sea surface temperature ( SST‾) and the difference between the warmest 30% where deep convection occurs and SST‾(SST ...
S. Fueglistaler
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Pliocene Warmth and Patterns of Climate Change Inferred From Paleoclimate Data Assimilation

AGU Advances
As the last time period when CO2 concentrations were near 400 ppm, the Pliocene Epoch (5.33–2.58 Ma) is a useful paleoclimate target for understanding future climate change. Existing estimates of global warming and climate sensitivity during the Pliocene
Jessica E. Tierney, Jonathan King, Matthew B. Osman, Jordan T. Abell, Natalie J. Burls, Ehsan Erfani, Vincent T. Cooper, Ran Feng   +7 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Understanding the Extreme Spread in Climate Sensitivity within the Radiative‐Convective Equilibrium Model Intercomparison Project

Journal of Advances in Modeling Earth Systems, 2020
The Radiative‐Convective Equilibrium Model Intercomparison Project (RCEMIP) consists of simulations at three fixed sea‐surface temperatures (SSTs: 295, 300, and 305 K) and thus allows for a calculation of the climate feedback parameter based on the ...
Tobias Becker, Allison A. Wing
doaj   +1 more source

How Much Human-Caused Global Warming Should We Expect with Business-As-Usual (BAU) Climate Policies? A Semi-Empirical Assessment

Energies, 2020
In order to assess the merits of national climate change mitigation policies, it is important to have a reasonable benchmark for how much human-caused global warming would occur over the coming century with “Business-As-Usual” (BAU ...
Ronan Connolly, Michael Connolly, Robert M. Carter, Willie Soon   +3 more
doaj   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source