Results 41 to 50 of about 900,949 (280)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Variabilité spatio-temporelle des séquences sèches en France depuis 1950

Cybergeo, 2021
This work proposes the study of spatial and temporal variability of rainfall droughts (no rain) on the scale of metropolitan France since the 1950s and for each of the four seasons (spring, summer, autumn, winter). A dry period approach makes it possible
Florian Raymond, Albin Ullmann
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Dynamic deep learning based super-resolution for the shallow water equations

Machine Learning: Science and Technology
Correctly capturing the transition to turbulence in a barotropic instability requires fine spatial resolution. To reduce computational cost, we propose a dynamic super-resolution approach where a transient simulation on a coarse mesh is frequently ...
Maximilian Witte, Fabrício R Lapolli, Philip Freese, Sebastian Götschel, Daniel Ruprecht, Peter Korn, Christopher Kadow   +6 more
doaj   +1 more source

State-dependence of climate sensitivity: attractor constraints and palaeoclimate regimes

, 2016
Equilibrium climate sensitivity (ECS) is a key predictor of climate change. However, it is not very well constrained, either by climate models or by observational data.
Ashwin, Peter, von der Heydt, Anna S.
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Antibiotic usage and the associated factors in the aquaculture farms of South-West Region of India

The Microbe
The fast-growing aquaculture industry has increased worldwide use of antibiotics which lead to a global emergence of antimicrobial resistance, posing serious threats to aquatic life, humans, and the environment.
Divya Nair, Ashokan Laila Achu, Padinchare Veettil Gayathri, Anas Abdulaziz, Girish Gopinath, S Sureshkumar, Devika Pillai   +6 more
doaj   +1 more source

The climate variability trio: stochastic fluctuations, El Niño, and the seasonal cycle

Geoscience Letters, 2023
Climate variability has distinct spatial patterns with the strongest signal of sea surface temperature (SST) variance residing in the tropical Pacific. This interannual climate phenomenon, the El Niño-Southern Oscillation (ENSO), impacts weather patterns
Malte F. Stuecker
doaj   +1 more source

Speleothem Paleoclimatology for the Caribbean, Central America, and North America [PDF]

, 2019
Speleothem oxygen isotope records from the Caribbean, Central, and North America reveal climatic controls that include orbital variation, deglacial forcing related to ocean circulation and ice sheet retreat, and the influence of local and remote sea ...
Arienzo, Monica M., Lachniet, Matthew, Oster, Jessica L., Sekhon, Natasha, Warken, Sophie F.   +4 more
core   +2 more sources

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source